Abstract

The reactivity of model amidines with general structure (NBu₄)[B₁₂H₁₁NHC(CH₃)HNCH(CH₂OTos)₂] under nucleophilic fluorination conditions has been investigated in the study. The obtained products have been characterized using multinuclear NMR and IR spectroscopies, RP-HPLC, and high-resolution mass spectrometry. The results obtained can be applied in the synthesis of similar derivatives containing ¹⁸F atoms for studying the pharmacokinetic parameters of BNCT agents using the PET method.

中文翻译：

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基于近十二硼酸根阴离子制备硼代脒含氟衍生物的方法研究

摘要

研究了具有通式结构(NBu ₄ )[B ₁₂ H ₁₁ NHC(CH ₃ )HNCH(CH ₂ OTos) ₂ ]的模型脒在亲核氟化条件下的反应活性。使用多核核磁共振和红外光谱、反相高效液相色谱和高分辨率质谱对所得产物进行了表征。所得结果可用于合成含有^18个F原子的类似衍生物，以使用PET方法研究BNCT药物的药代动力学参数。