Development of a physiologically based pharmacokinetic model for levetiracetam in patients with renal impairment to guide dose adjustment based on steady-state peak/trough concentrations,Xenobiotica

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Development of a physiologically based pharmacokinetic model for levetiracetam in patients with renal impairment to guide dose adjustment based on steady-state peak/trough concentrations
Xenobiotica ( IF 1.8 ) Pub Date : 2024-02-21 , DOI: 10.1080/00498254.2024.2317888
Rongrong Wang ₁ , Tianlin Wang ₁ , Xueliang Han ₂ , Mengli Chen ₁ , Shu Li ₁

Affiliation

Levetiracetam may cause acute renal failure and myoclonic encephalopathy at high plasma levels, particularly in patients with renal impairment. The aim of this study was to develop a physiologicall...

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