Post-weaning diarrhea in pigs is a considerable challenge in the pig farming industry due to its effect on animal welfare and production costs, as well as the large volume of antibiotics, which are used to treat diarrhea in pigs after weaning. Previous studies have revealed loci on SSC6 and SSC13 associated with susceptibility to specific diarrhea causing pathogens. This study aimed to identify new genetic loci for resistance to diarrhea based on phenotypic data. In depth clinical characterization of diarrhea was performed in 257 pigs belonging to two herds during the first 14 days post weaning. The daily diarrhea assessments were used for the classification of pigs into case and control groups. Pigs were assigned to case and control groups based only on the incidence of diarrhea in the second week of the study in order to differentiate between differences in etiology. Genome-wide association studies and metabolomics association analysis were performed in order to identify new biological determinants for diarrhea susceptibility. With the present work, we revealed a new locus for diarrhea resistance on SSC16. Furthermore, studies of metabolomics in the same pigs revealed one metabolite associated with diarrhea.

中文翻译：

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鉴定仔猪断奶后腹泻的新遗传决定因素

猪断奶后腹泻是养猪业面临的一个重大挑战，因为它会影响动物福利和生产成本，而且需要大量抗生素来治疗猪断奶后腹泻。先前的研究揭示了 SSC6 和 SSC13 上的位点与特定腹泻病原体的易感性相关。本研究旨在根据表型数据确定新的抗腹泻遗传位点。在断奶后的前 14 天内，对属于两个猪群的 257 头猪进行了腹泻的深入临床特征分析。每日腹泻评估用于将猪分为病例组和对照组。仅根据研究第二周的腹泻发生率将猪分配至病例组和对照组，以区分病因学差异。进行全基因组关联研究和代谢组学关联分析，以确定腹泻易感性的新生物决定因素。通过目前的工作，我们揭示了 SSC16 上的一个新的腹泻抵抗位点。此外，对同一头猪的代谢组学研究揭示了一种与腹泻相关的代谢物。