The identification of progression in patients with fibrosing non-idiopathic pulmonary fibrosis (IPF) interstitial lung diseases (ILDs) represents an ongoing clinical challenge. Lung function decline alone may have significant limitations in the detection of clinically significant progression. We hypothesized that longitudinal changes of 6-min walk distance (6MWD) from baseline, simultaneously considered with measures of lung function, may independently predict survival and identifying clinically significant progression of disease.

中文翻译：

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使用 6 分钟步行距离预测纤维化非 IPF 间质性肺疾病的无肺移植生存率

纤维化非特发性肺纤维化 (IPF) 间质性肺疾病 (ILD) 患者进展的识别是一项持续的临床挑战。单独的肺功能下降可能在检测临床显着进展方面具有显着局限性。我们假设，6 分钟步行距离 (6MWD) 相对于基线的纵向变化，同时考虑肺功能测量，可以独立预测生存并确定临床上显着的疾病进展。