c-Fos, a member of the immediate early gene, serves as a widely used marker of neuronal activation induced by various types of brain damage. In addition, c-Fos is believed to play a regulatory role in DNA damage repair. This paper reviews the literature on c-Fos' involvement in the regulation of DNA damage repair and indicates that genes of the Fos family can be induced by various forms of DNA damage. In addition, cells lacking c-Fos have difficulties in DNA repair. c-Fos is involved in tumorigenesis and progression as a proto-oncogene that maintains cancer cell survival, which may also be related to DNA repair. c-Fos may impact the repair of DNA damage by regulating the expression of downstream proteins, including ATR, ERCC1, XPF, and others. Nonetheless, the underlying mechanisms necessitate further exploration.

中文翻译：

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c-Fos 在 DNA 损伤修复中的作用

c-Fos 是立即早期基因的成员，是广泛使用的由各种类型的脑损伤引起的神经元激活的标记物。此外，c-Fos被认为在DNA损伤修复中发挥调节作用。本文回顾了 c-Fos 参与 DNA 损伤修复调控的文献，指出 Fos 家族的基因可以被各种形式的 DNA 损伤诱导。此外，缺乏c-Fos的细胞在DNA修复方面存在困难。 c-Fos作为维持癌细胞存活的原癌基因参与肿瘤的发生和进展，这也可能与DNA修复有关。 c-Fos 可能通过调节下游蛋白（包括 ATR、ERCC1、XPF 等）的表达来影响 DNA 损伤的修复。尽管如此，其潜在机制仍需要进一步探索。