Self-renewing cancer stem cells drive tumor initiation and progression and represent a major target for therapeutic development. A study now shows that vanoxerine, a dopamine transporter antagonist, precisely inhibits this cell population in colorectal cancer, which leads to attenuation of tumor initiation and increased infiltration by immune cells.

中文翻译：

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重新利用多巴胺转运蛋白拮抗剂伐诺司林治疗结直肠癌

自我更新的癌症干细胞驱动肿瘤的发生和进展，是治疗开发的主要目标。现在的一项研究表明，多巴胺转运蛋白拮抗剂伐诺司林可以精确抑制结直肠癌中的这种细胞群，从而减弱肿瘤的发生并增加免疫细胞的浸润。