Vincazalidine A, a unique bisindole alkaloid from Catharanthus roseus,Journal of Natural Medicines

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Vincazalidine A, a unique bisindole alkaloid from Catharanthus roseus
Journal of Natural Medicines ( IF 3.3 ) Pub Date : 2024-02-12 , DOI: 10.1007/s11418-023-01775-x
Yusuke Hirasawa , Ayaka Kase , Akie Okamoto , Keigo Suzuki , Mizuki Hiroki , Toshio Kaneda , Nahoko Uchiyama , Hiroshi Morita

A new dimeric indole alkaloid, vincazalidine A consisting of an aspidosperma type and a modified iboga type with 1-azatricyclo ring system consisting of one azepane and two piperidine rings coupled with an oxazolidine ring was isolated from Catharanthus roseus, and the structure including absolute stereochemistry was elucidated on the basis of spectroscopic data as well as DP4 statistical analysis. Vincazalidine A induced G2 arrest and subsequent apoptosis in human lung carcinoma cell line, A549 cells.

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更新日期：2024-02-13

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