Abstract

A simple and efficient method for the synthesis of spiropyridazine-benzosultams has been developed by means of [4 + 2] annulation reaction of 3-substituted benzoisothiazole 1,1-dioxides with 1,2-diaza-1,3-dienes. This approach displays advantages such as mild reaction conditions, wide substrate range tolerance, simple operation, compatibility with gram-scale preparation.

Beilstein J. Org. Chem. 2024, 20, 280–286. doi:10.3762/bjoc.20.29

中文翻译：

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3-取代苯并异噻唑1,1-二氧化物与1,2-二氮杂-1,3-二烯的[4+2]成环反应合成螺哒嗪-苯并磺内酰胺

摘要

通过3-取代苯并异噻唑1,1-二氧化物与1,2-二氮杂-1,3-二烯的[4+2]环化反应，开发了一种简单有效的螺哒嗪苯并磺内酰胺合成方法。该方法具有反应条件温和、底物耐受范围宽、操作简单、适合克级制备等优点。

贝尔斯坦 J. 组织。化学。 2024, 20, 280–286。 doi:10.3762/bjoc.20.29