Abstract

Purpose

High-grade gliomas (HGG) are aggressive cancers, and their recurrence is inevitable, despite advances in treatment options. While repeated tumor resection has been shown to increase survival rate, its impact on quality of life is not clearly defined. To address this gap, we compared quality of life (QoL) changes in HGG patients who underwent first-time (FTR) versus repeat surgical resections (RSR) for management of recurrence.

Methods

Forty-four adults with HGG who underwent tumor resection were included in this study and classified into either the FTR group (n = 23) or the RSR group (n = 21). All patients completed comprehensive neuropsychological evaluations that included the Functional Assessment of Cancer Therapy-General (FACT-G) and Functional Assessment of Cancer Therapy-Cognitive Function (FACT-Cog) scales, pre-operatively and at two weeks post-operatively.

Results

There was no difference between the FTR and RSR groups in any of the QoL indices (all p > .05), except for improved emotional well-being and worsened social well-being, suggesting minimal detrimental effects of repeat surgeries on QoL in comparison to first time surgery.

Conclusions

These results suggest that repeated resection is a viable strategy in certain cases for management of HGG recurrence, with similar impact on QoL as observed in patients undergoing first time surgery. These encouraging outcomes provide useful insight to guide treatment strategies and patient and clinician decision making to optimize surgical and functional outcomes.

中文翻译：

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反复手术切除治疗高级别胶质瘤及其对生活质量的影响

摘要

目的

高级别胶质瘤（HGG）是一种侵袭性癌症，尽管治疗方案不断进步，但它们的复发是不可避免的。虽然重复肿瘤切除已被证明可以提高生存率，但其对生活质量的影响尚不清楚。为了解决这一差距，我们比较了首次接受手术切除 (FTR) 与再次手术切除 (RSR) 治疗复发的 HGG 患者的生活质量 (QoL) 变化。

方法

本研究纳入了 44 名接受肿瘤切除术的 HGG 成人，并分为 FTR 组 (n = 23) 或 RSR 组 (n = 21)。所有患者在术前和术后两周完成了全面的神经心理学评估，包括癌症治疗一般功能评估 (FACT-G) 和癌症治疗认知功能功能评估 (FACT-Cog) 量表。

结果

 除了情绪健康改善和社交福祉恶化之外，FTR 组和 RSR 组之间的任何 QoL 指数均无差异（所有p > .05），这表明与其他组相比，重复手术对 QoL 的不利影响最小。第一次手术。

结论

这些结果表明，在某些 HGG 复发病例中，重复切除是一种可行的治疗策略，对生活质量的影响与首次手术患者中观察到的相似。这些令人鼓舞的结果为指导治疗策略以及患者和临床医生的决策提供了有用的见解，以优化手术和功能结果。