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Halogenation of Aldoximes. A Versatile Reaction for the Synthesis of Highly Functionalized Hydroximoyl Chlorides and Furazan N-Oxides
Russian Journal of Organic Chemistry ( IF 0.8 ) Pub Date : 2024-02-14 , DOI: 10.1134/s1070428023120217
A. Hernández-Calva , L. Meléndez-Balbuena , M. Arroyo-Carranza , A. Ramírez-Monroy

Abstract

Halogenation of aromatic aldoximes with N-chlorosuccinimide under mild conditions produced a variety of highly functionalized compounds, including the corresponding hydroximoyl chlorides and furazan N-oxides. In some cases, the reaction was accompanied by chlorination of the aromatic ring. The initial aldoximes were prepared from substituted benzaldehydes and hydroxylamine hydrochloride. The structure of some of the synthesized compounds was determined by X-ray analysis.



中文翻译:

醛肟的卤化。合成高官能化羟基酰氯和呋喃氮氧化物的多功能反应

摘要

芳香醛肟与N-氯代琥珀酰亚胺在温和条件下卤化产生多种高度官能化的化合物,包括相应的羟肟酰氯和呋喃N-氧化物。在某些情况下,反应伴随着芳环的氯化。最初的醛肟由取代苯甲醛和盐酸羟胺制备。通过X射线分析确定了一些合成化合物的结构。

更新日期:2024-02-15
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