Developing inhibitors for SH2 domains is challenging due to their shallow pockets and highly charged ligands. Structure-guided drug design has enabled the discovery of a cell-permeable covalent inhibitor of the SOCS2 SH2 domain, a key regulator of cytokine signaling pathways.

中文翻译：

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SH2结构域的成药性被揭开

由于 SH2 结构域的浅口袋和高电荷配体，开发 SH2 结构域抑制剂具有挑战性。结构引导的药物设计使得我们能够发现 SOCS2 SH2 结构域的细胞渗透性共价抑制剂，SOCS2 SH2 结构域是细胞因子信号传导途径的关键调节因子。