The transcription factor, known as basic leucine zipper ATF-like 3 (BATF3), is a crucial contributor to the development of conventional type 1 dendritic cells (cDC1), which is definitely required for priming CD8 + T cell-mediated immunity against intracellular pathogens and malignancies. In this respect, BATF3-dependent cDC1 can bring about immunological tolerance, an autoimmune response, graft immunity, and defense against infectious agents such as viruses, microbes, parasites, and fungi. Moreover, the important function of cDC1 in stimulating CD8 + T cells creates an excellent opportunity to develop a highly effective target for vaccination against intracellular pathogens and diseases. BATF3 has been clarified to control the development of CD8α⁺ and CD103⁺ DCs. The presence of BATF3-dependent cDC1 in the tumor microenvironment (TME) reinforces immunosurveillance and improves immunotherapy approaches, which can be beneficial for cancer immunotherapy. Additionally, BATF3 acts as a transcriptional inhibitor of Treg development by decreasing the expression of the transcription factor FOXP3. However, when overexpressed in CD8 + T cells, it can enhance their survival and facilitate their transition to a memory state. BATF3 induces Th9 cell differentiation by binding to the IL-9 promoter through a BATF3/IRF4 complex. One of the latest research findings is the oncogenic function of BATF3, which has been approved and illustrated in several biological processes of proliferation and invasion.

这种转录因子被称为碱性亮氨酸拉链 ATF 样 3 (BATF3)，是传统 1 型树突细胞 (cDC1) 发育的重要贡献者，而 cDC1 是启动 CD8 + T 细胞介导的针对细胞内病原体的免疫所必需的和恶性肿瘤。在这方面，BATF3依赖的cDC1可以带来免疫耐受、自身免疫反应、移植免疫以及针对病毒、微生物、寄生虫和真菌等传染源的防御。此外，cDC1在刺激CD8+T细胞方面的重要功能为开发针对细胞内病原体和疾病的疫苗接种的高效靶点创造了绝佳的机会。 BATF3 已被明确控制 CD8α ⁺和 CD103 ⁺ DC 的发育。肿瘤微环境 (TME) 中 BATF3 依赖性 cDC1 的存在增强了免疫监视并改进了免疫治疗方法，这可能有利于癌症免疫治疗。此外，BATF3 通过降低转录因子 FOXP3 的表达，充当 Treg 发育的转录抑制剂。然而，当在 CD8 + T 细胞中过度表达时，它可以增强它们的存活率并促进它们向记忆状态的转变。 BATF3 通过 BATF3/IRF4 复合物与 IL-9 启动子结合，诱导 Th9 细胞分化。最新的研究发现之一是 BATF3 的致癌功能，该功能已在增殖和侵袭的多种生物过程中得到认可和说明。