Metabolic syndrome affects more than one in three adults and is associated with increased risk of diabetes, cardiovascular disease, and all-cause mortality. Muscle insulin resistance is a major contributor to the development of the metabolic syndrome. Studies in mice have linked skeletal muscle sarcoplasmic reticulum (SR) phospholipid composition to sarcoplasmic/endoplasmic reticulum Ca-ATPase activity and insulin sensitivity. To determine if the presence of metabolic syndrome alters specific phosphatidylcholine (PC) and phosphatidylethanolamine (PE) species in human SR, we compared SR phospholipid composition in skeletal muscle from sedentary subjects with metabolic syndrome and sedentary control subjects without metabolic syndrome. Both total PC and total PE were significantly decreased in skeletal muscle SR of sedentary metabolic syndrome patients compared with sedentary controls, particularly in female participants, but there was no difference in the PC:PE ratio between groups. Total SR PC levels, but not total SR PE levels or PC:PE ratio, were significantly negatively correlated with BMI, waist circumference, total fat, visceral adipose tissue, triglycerides, fasting insulin, and homeostatic model assessment for insulin resistance. These findings are consistent with the existence of a relationship between skeletal muscle SR PC content and insulin resistance in humans.

中文翻译：

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人体骨骼肌肌浆网磷脂减少与代谢综合征相关

代谢综合征影响超过三分之一的成年人，并与糖尿病、心血管疾病和全因死亡率风险增加相关。肌肉胰岛素抵抗是代谢综合征发生的主要原因。对小鼠的研究已将骨骼肌肌浆网 (SR) 磷脂组成与肌浆/内质网 Ca-ATP 酶活性和胰岛素敏感性联系起来。为了确定代谢综合征的存在是否会改变人类 SR 中特定的磷脂酰胆碱 (PC) 和磷脂酰乙醇胺 (PE) 种类，我们比较了患有代谢综合征的久坐受试者和没有代谢综合征的久坐对照受试者骨骼肌中的 SR 磷脂组成。与久坐的对照组相比，久坐代谢综合征患者的骨骼肌 SR 中的总 PC 和总 PE 均显着降低，尤其是女性参与者，但组间 PC:PE 比率没有差异。总 SR PC 水平，而非总 SR PE 水平或 PC:PE 比值，与 BMI、腰围、总脂肪、内脏脂肪组织、甘油三酯、空腹胰岛素和胰岛素抵抗稳态模型评估显着负相关。这些发现与人类骨骼肌 SR PC 含量和胰岛素抵抗之间存在关系一致。