The metabolism of the orexin-1 selective receptor antagonist nivasorexant,Xenobiotica

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The metabolism of the orexin-1 selective receptor antagonist nivasorexant
Xenobiotica ( IF 1.8 ) Pub Date : 2024-03-01 , DOI: 10.1080/00498254.2024.2319811
Alexander Treiber ₁ , Swen Seeland ₁ , Belal Haschimi ₁ , Aude Weigel ₁ , Jodi T. Williams ₂ , Jerome Gabillet ₂

Affiliation

Nivasorexant was the first orexin-1 selective receptor antagonist entering clinical development. Despite encouraging preclinical evidence in animal models, a proof-of-concept trial in binge-eating ...

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