We aimed to examine the relationship between lifetime exposure to adverse childhood experiences (ACEs) during the first decade of life and recent pain features reported in early adolescence. We conducted a prospective study using data from 4564 adolescent Generation XXI birth cohort participants recruited in 2005–2006. Adverse childhood experiences were reported by children at ages 10 and 13 years using a 15-item questionnaire. Recent pain features (e.g., any pain, pain sites, recurrent pain intensity, and recurrent pain duration) were measured using structured questionnaires, including the Luebeck pain screening questionnaire at age 13. Using hierarchical binary and multinomial logistic regression analyses with progressive adjustments for confounders, we estimated the associations [adjused odds ratios (aOR) with their 95% confidence intervals (95% CI)] between exposure to ACEs at 10 and pain features at 13 years. The study revealed a statistically significant association between exposure to ACEs reported at age 10 and any pain experienced at age 13 (OR = 1.09; 95% CI [1.07, 1.12]). Even after accounting for the newly reported ACEs at age 13, the association with ACEs at age 10, remained significant (aOR = 1.11 [95% CI, 1.08–1.14]). Consistent patterns were observed when the number of pain sites, recurrent pain intensity, or recurrent pain duration were used as outcome variables instead of any pain at age 13. Adverse childhood experiences occurring during the first decade of life predict the onset of pain features during early adolescence. Consequently, childhood exposure to adversity should be considered a pivotal initial exposure in a pathway leading to chronic pain later in life.

中文翻译：

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不良童年经历与青春期早期身体疼痛之间的关联

我们的目的是研究生命头十年期间一生所经历的不良童年经历 (ACE) 与青春期早期报告的近期疼痛特征之间的关系。我们使用 2005 年至 2006 年招募的 4564 名第 21 代青少年出生队列参与者的数据进行了一项前瞻性研究。使用包含 15 项的调查问卷，10 岁和 13 岁的儿童报告了不良的童年经历。使用结构化问卷（包括 13 岁时的吕贝克疼痛筛查问卷）测量近期疼痛特征（例如任何疼痛、疼痛部位、复发性疼痛强度和复发性疼痛持续时间）。使用分层二元和多项逻辑回归分析，并对混杂因素进行逐步调整，我们估计了 10 岁时接触 ACE 与 13 岁时疼痛特征之间的关联[调整优势比 (aOR) 及其 95% 置信区间 (95% CI)]。该研究揭示了 10 岁时报告的 ACE 暴露与 13 岁时经历的任何疼痛之间存在统计学显着关联（OR = 1.09；95% CI [1.07, 1.12]）。即使考虑了 13 岁时新报告的 ACE，与 10 岁时 ACE 的相关性仍然显着（aOR = 1.11 [95% CI，1.08–1.14]）。当疼痛部位的数量、复发性疼痛强度或复发性疼痛持续时间而不是 13 岁时的任何疼痛作为结果变量时，观察到了一致的模式。在生命的第一个十年中发生的不良童年经历可以预测早期疼痛特征的发作。青春期。因此，童年时期经历的逆境应该被视为导致日后慢性疼痛的关键初始经历。