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Development of certain benzylidene coumarin derivatives as anti-prostate cancer agents targeting EGFR and PI3Kβ kinases
Journal of Enzyme inhibition and Medicinal Chemistry ( IF 5.6 ) Pub Date : 2024-02-13 , DOI: 10.1080/14756366.2024.2311157 Mohamed Elagawany 1 , Lina M. A. Abdel Ghany 2 , Tarek S. Ibrahim 3 , Abdulrhman S. Alharbi 4 , Mohamed S. Abdel-Aziz 5 , Eman M. El-labbad 6, 7 , Noha Ryad 8
Journal of Enzyme inhibition and Medicinal Chemistry ( IF 5.6 ) Pub Date : 2024-02-13 , DOI: 10.1080/14756366.2024.2311157 Mohamed Elagawany 1 , Lina M. A. Abdel Ghany 2 , Tarek S. Ibrahim 3 , Abdulrhman S. Alharbi 4 , Mohamed S. Abdel-Aziz 5 , Eman M. El-labbad 6, 7 , Noha Ryad 8
Affiliation
Novel coumarin derivatives were synthesised and tested for their cytotoxicity against human cancer cells (PC-3 and MDA-MB-231). Compounds 5, 4b, and 4a possessed potent cytotoxic activity against P...
中文翻译：
开发某些亚苄基香豆素衍生物作为靶向 EGFR 和 PI3Kβ 激酶的抗前列腺癌药物
合成了新型香豆素衍生物并测试了其对人类癌细胞（PC-3 和 MDA-MB-231）的细胞毒性。化合物 5、4b 和 4a 具有针对 P...的有效细胞毒活性。
更新日期：2024-02-16
中文翻译：
开发某些亚苄基香豆素衍生物作为靶向 EGFR 和 PI3Kβ 激酶的抗前列腺癌药物
合成了新型香豆素衍生物并测试了其对人类癌细胞（PC-3 和 MDA-MB-231）的细胞毒性。化合物 5、4b 和 4a 具有针对 P...的有效细胞毒活性。
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