Ubiquitination is an essential process that curtails cellular levels of damaged and redundant proteins. Chemical biologists have harnessed this natural system to induce the degradation of disease-relevant proteins. We reflect here on the potential of ‘degraders’ for targeted selectivity, and discuss the role of computer-aided drug design in shaping future advances.

中文翻译：

---

降解剂对泛素化的化学重连及其选择性途径

泛素化是减少受损和冗余蛋白质细胞水平的重要过程。化学生物学家利用这种自然系统来诱导与疾病相关的蛋白质的降解。我们在此反思“降解剂”在靶向选择性方面的潜力，并讨论计算机辅助药物设计在塑造未来进展中的作用。