Although intravitreal (IVT) injections provide several advantages in treating posterior segment eye diseases, several associated challenges remain. The current study uses the finite element method (FEM) to highlight the effect of IVT needle rotation along the insertion axis on the reaction forces and deformation inside the eye. A comparison of the reaction forces at the eye’s key locations has been made with and without rotation. In addition, a sensitivity analysis of various parameters, such as the needle’s angular speed, insertion location, angle, gauge, shape, and intraocular pressure (IOP), has been carried out to delineate the individual parameter’s effect on reaction forces during rotation. Results demonstrate that twisting the needle significantly reduces the reaction forces at the penetration location and throughout the needle travel length, resulting in quicker penetration. Moreover, ocular biomechanics are influenced by needle insertion location, angle, shape, size, and IOP. The reaction forces incurred by the patient may be reduced by using a bevel needle of the higher gauge when inserted close to the normal of the local scleral surface toward the orra serrata within the Pars Plana region. Results obtained from the current study can deepen the understanding of the twisting needle’s interaction with the ocular tissue.

尽管玻璃体内（IVT）注射在治疗眼后段疾病方面具有多种优势，但仍然存在一些相关的挑战。目前的研究使用有限元方法 (FEM) 来强调 IVT 针沿插入轴旋转对眼睛内部反作用力和变形的影响。比较了旋转和不旋转时眼睛关键位置处的反作用力。此外，还对各种参数（例如针的角速度、插入位置、角度、规格、形状和眼内压（IOP））进行了灵敏度分析，以描述各个参数对旋转过程中反作用力的影响。结果表明，扭转针显着降低了穿刺位置和整个针行程长度的反作用力，从而实现更快的穿刺。此外，眼部生物力学受到针插入位置、角度、形状、尺寸和眼压的影响。当接近局部巩膜表面的法线插入平坦部区域内的锯齿缘时，可以通过使用较高规格​​的斜面针来减少患者产生的反作用力。当前研究获得的结果可以加深对扭针与眼组织相互作用的理解。