Mental illness (MI) and substance use (SU) are highly prevalent among people with HIV (PWH) and impact care outcomes. The Substance Abuse and Mental Illness Symptoms Screener (SAMISS) is a validated screener for MI and SU, but it is unknown how screening results at entry to care correlate with subsequent HIV outcomes. This is a retrospective chart review of individuals newly diagnosed with HIV between 2016 and 2019 in a Southern US, safety-net clinic. Baseline demographics, HIV risk factors, socioeconomic variables, and SAMISS screening scores were collected. Outcomes included retention in care, achieving virologic suppression (VS), and continuous VS. Data analyses included stepwise Cox and logistic multivariate regression modeling. Among the 544 newly diagnosed PWH, mean age was 35, 76% were male, 46% non-Hispanic Black, 40% Hispanic/other. Overall, 35% screened positive for SU and 41% for MI. A positive SU (odds ratio (OR) 0.66, p = 0.04) or MI (OR 0.65, p = 0.03) SAMISS screening was associated with lower retention in care in univariate analysis, but was not statistically significant after adjusting for other variables. Positive SAMISS screening for SU and MI were both associated with reduced continuous VS in univariate and multivariate analyses (SU: adjusted OR (aOR) 0.67, p = 0.05; MI: aOR 0.66, p = 0.03). SAMISS is a useful tool for prospectively identifying individuals at risk for low retention in care and for not achieving sustained VS. Future interventions guided by SAMISS may improve HIV care continuum outcomes.

精神疾病 (MI) 和药物滥用 (SU) 在艾滋病毒感染者 (PWH) 中非常普遍，并影响护理结果。药物滥用和精神疾病症状筛查仪 (SAMISS) 是一种经过验证的 MI 和 SU 筛查仪，但尚不清楚进入护理时的筛查结果与随后的 HIV 结果有何关联。这是对 2016 年至 2019 年在美国南部安全网诊所新诊断出艾滋病毒的个人的回顾性图表审查。收集基线人口统计数据、HIV 危险因素、社会经济变量和 SAMISS 筛查评分。结果包括保留护理、实现病毒学抑制 (VS) 和持续 VS。数据分析包括逐步 Cox 和逻辑多元回归模型。在 544 名新诊断的感染者中，平均年龄为 35 岁，76% 为男性，46% 为非西班牙裔黑人，40% 为西班牙裔/其他人。总体而言，35% 的 SU 筛查呈阳性，41% 的 MI 筛查呈阳性。在单变量分析中，SU（优势比 (OR) 0.66，p = 0.04）或 MI（OR 0.65，p = 0.03）SAMISS 筛查阳性与较低的护理保留率相关，但在调整其他变量后不具有统计学意义。在单变量和多变量分析中，SU 和 MI 的 SAMISS 筛查阳性均与连续 VS 降低相关（SU：调整后 OR (aOR) 0.67，p = 0.05；MI：aOR 0.66，p = 0.03）。 SAMISS 是一个有用的工具，可用于前瞻性地识别存在护理保留率低和无法实现持续 VS 风险的个人。 SAMISS 指导的未来干预措施可能会改善艾滋病毒护理的连续结果。