: Epidemiological trends in cancer research show that lung cancer can affect up to 1 in 15 men and 1 in 17 women. With incidence rates as high as these and significant associated mortality and morbidity, it is no wonder that lung cancer is one of the main areas of research focused on cancer. Advances in targeted treatments and specialized irradiation protocols have allowed the treatment of more advanced cases. However, as the patient numbers grow, so does the need for cancer-preventive strategies. The present narrative review focuses on soy isoflavones' role in the chemoprevention of lung cancer and their possible role in therapeutic adjuncts. Laboratory studies on lung cancer cell lines have shown that isoflavones can induce apoptosis, tamper with the expression of proliferative molecular pathways, and even reduce tumor angiogenesis. Additionally, population-level studies have emerged that correlate the consumption of isoflavonoids with reduced risk for the development of lung cancer. Interestingly enough, the literature also contains small-scale studies with evidence of isoflavones being effective chemotherapeutic adjuncts that are currently understudied. Our literature review underlines such findings and provides a call for the enhancement of research regarding naturally occurring dietary products with possible anticarcinogenic effects.

中文翻译：

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异黄酮作为肺癌化学预防剂的用途及其在放射增敏治疗中的意义

：癌症研究的流行病学趋势表明，肺癌可影响多达五分之一的男性和十分之一的女性。由于发病率如此之高以及相关的死亡率和发病率显着，难怪肺癌成为癌症研究的主要领域之一。针对性治疗和专门照射方案的进步使得能够治疗更晚期的病例。然而，随着患者数量的增加，对癌症预防策略的需求也在增加。本综述重点关注大豆异黄酮在肺癌化学预防中的作用及其在治疗辅助中的可能作用。对肺癌细胞系的实验室研究表明，异黄酮可以诱导细胞凋亡，篡改增殖分子途径的表达，甚至减少肿瘤血管生成。此外，人群水平的研究表明，异黄酮类化合物的摄入量与降低患肺癌的风险相关。有趣的是，文献中还包含小规模研究，证据表明异黄酮是目前尚未充分研究的有效化疗辅助剂。我们的文献综述强调了这些发现，并呼吁加强有关可能具有抗癌作用的天然膳食产品的研究。