: Liver fibrosis, characterized by the overproduction of extracellular matrix proteins within liver tissue, poses a rising global health concern. However, no approved antifibrotic drugs are currently available, highlighting the critical need for understanding the molecular mechanisms of liver fibrosis. This knowledge could not only aid in developing therapies but also enable early intervention, enhance disease prediction, and improve our understanding of the interaction between various underlying conditions and the liver. Notably, natural products used in traditional medicine systems worldwide and demonstrating diverse biochemical and pharmacological activities are increasingly recognized for their potential in treating liver fibrosis. This review aims to comprehensively understand liver fibrosis, emphasizing the molecular mechanisms and advancements in exploring natural products' antifibrotic potential over the past five years. It also acknowledges the challenges in their development and seeks to underscore their potency in enhancing patient prognosis and reducing the global burden of liver disease.

中文翻译：

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天然产物在肝纤维化治疗中的作用：五年回顾

：肝纤维化的特征是肝组织内细胞外基质蛋白的过量产生，引起了全球日益严重的健康问题。然而，目前还没有批准的抗纤维化药物，这凸显了了解肝纤维化分子机制的迫切需要。这些知识不仅可以帮助开发治疗方法，还可以进行早期干预，增强疾病预测，并提高我们对各种潜在疾病与肝脏之间相互作用的理解。值得注意的是，全世界传统医学系统中使用的天然产物并表现出多种生化和药理活性，其治疗肝纤维化的潜力越来越受到人们的认可。本综述旨在全面了解肝纤维化，强调过去五年来探索天然产物抗纤维化潜力的分子机制和进展。它还承认它们发展中的挑战，并试图强调它们在改善患者预后和减轻全球肝病负担方面的潜力。