Auditory processing in mammals begins in the peripheral inner ear and extends to the auditory cortex. Sound is transduced from mechanical stimuli into electrochemical signals of hair cells, which relay auditory information via the primary auditory neurons to cochlear nuclei. Information is subsequently processed in the superior olivary complex, lateral lemniscus, and inferior colliculus and projects to the auditory cortex via the medial geniculate body in the thalamus. Recent advances have provided valuable insights into the development and functioning of auditory structures, complementing our understanding of the physiological mechanisms underlying auditory processing. This comprehensive review explores the genetic mechanisms required for auditory system development from the peripheral cochlea to the auditory cortex. We highlight transcription factors and other genes with key recurring and interacting roles in guiding auditory system development and organization. Understanding these gene regulatory networks holds promise for developing novel therapeutic strategies for hearing disorders, benefiting millions globally.Expected final online publication date for the Annual Review of Neuroscience, Volume 47 is July 2024. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

中文翻译：

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听觉分子乐团的和谐：从耳朵到大脑的发育机制

哺乳动物的听觉处理始于内耳周围并延伸至听觉皮层。声音从机械刺激转变成毛细胞的电化学信号，毛细胞将听觉信息通过初级听觉神经元传递到耳蜗核。随后，信息在上橄榄复合体、外侧丘系和下丘中进行处理，并通过丘脑的内侧膝状体投射到听觉皮层。最近的进展为听觉结构的发育和功能提供了宝贵的见解，补充了我们对听觉处理生理机制的理解。这篇全面的综述探讨了从外周耳蜗到听觉皮层的听觉系统发育所需的遗传机制。我们强调转录因子和其他基因在指导听觉系统发育和组织方面具有关键的重复和相互作用的作用。了解这些基因调控网络有望开发新的听力障碍治疗策略，使全球数百万人受益。《神经科学年度评论》第 47 卷的预计最终在线出版日期为 2024 年 7 月。请参阅 http://www.annualreviews.org/修订后的估计的页面/期刊/出版物。