Purpose

Nocturnal asthma is a sign of asthma worsening and could be partially due to more fluid drawn into the thorax during sleep by gravitational force and/or pharyngeal collapse in those with obstructive sleep apnea. Wearing compression stockings during the day reduces fluid shift from the legs to the neck overnight. However, the potential effect of wearing compression stockings to reduce fluid accumulation in the leg and to improve nocturnal small airway narrowing in patients with asthma has not been investigated. This study investigates whether reducing leg fluid volume by wearing compression stockings during the day would attenuate small airway narrowing in patients with asthma before and after sleep.

Methods

We enrolled 11 participants with asthma. All participants underwent overnight polysomnography with or without wearing compression stockings for 2 weeks. Before and after sleep, leg fluid volume (LFV) was measured by bioelectrical impedance, and airway narrowing was primarily assessed by respiratory system resistance and reactance at 5 Hz (R5 and X5 respectively) using oscillometry.

Results

After 2 weeks of wearing compression stockings, the LFV measured in the evening was reduced (∆ = − 192.6 ± 248.3 ml, p = 0.02), and R5 and X5 improved (∆ = − 0.7 ± 0.9 cmH₂O/L/s, p = 0.03 and 0.2 ± 1.4 cmH₂O/L/s, p = 0.05 respectively). No changes were observed in the morning.

Conclusions

Preventing fluid retention in the legs by wearing compression stockings for 2 weeks during the day, reduced LFV and airway narrowing in the evening in all participants with asthma, but not in the morning after sleep.

中文翻译：

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一项初步研究，旨在评估穿压力袜预防腿部液体潴留对轻度哮喘患者夜间气道狭窄的影响

目的

夜间哮喘是哮喘恶化的征兆，部分原因可能是由于睡眠时重力和/或阻塞性睡眠呼吸暂停患者的咽部塌陷导致更多液体进入胸腔。白天穿着压力袜可以减少夜间液体从腿部转移到颈部的情况。然而，穿着压力袜对于减少腿部积液和改善哮喘患者夜间小气道狭窄的潜在效果尚未进行研究。这项研究调查了白天穿压力袜来减少腿部液体量是否会减轻哮喘患者在睡眠前后的小气道狭窄。

方法

我们招募了 11 名患有哮喘的参与者。所有参与者在穿或不穿压力袜的情况下都接受了为期两周的过夜多导睡眠图检查。睡眠前后，通过生物电阻抗测量腿部液体量 (LFV)，气道狭窄主要通过使用示波法的呼吸系统阻力和 5 Hz 电抗（分别为 R5 和 X5）来评估。

结果

穿着压力袜两周后，晚上测得的 LFV 降低（Δ = − 192.6 ± 248.3 ml，p  = 0.02），R5 和 X5 改善（Δ = − 0.7 ± 0.9 cmH ₂ O/L/s，p  = 0.03 和 0.2 ± 1.4 cmH ₂ O/L/s，p  = 0.05 分别）。早上没有观察到任何变化。

结论

通过白天穿着压力袜两周来防止腿部液体潴留，所有哮喘参与者在晚上都可以减少 LFV 和气道狭窄，但在睡眠后的早晨则不会。