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Correction: Collusion of α-Synuclein and Aβ aggravating co-morbidities in a novel prion-type mouse model
Molecular Neurodegeneration ( IF 15.1 ) Pub Date : 2024-02-16 , DOI: 10.1186/s13024-024-00710-2
Grace M. Lloyd , Jess-Karan S. Dhillon , Kimberly-Marie M. Gorion , Cara Riffe , Susan E. Fromholt , Yuxing Xia , Benoit I. Giasson , David R. Borchelt

Correction: Molecular Neurodegeneration 16, 63 (2021)

https://doi.org/10.1186/s13024-021-00486-9

The authors wish to correct an error in Fig. 7A of the original article [1]. We have determined that the representative image of a hemibrain shown for 10 month-old, PBS-injected, nontransgenic (nTg) mice in panel A is incorrect. Due to a labeling error of the digital file name, the brain image shown was actually from a 10 month-old, PBS-injected, wild-type αSyn (M20) animal. The corrected panel for Fig. 7A is provided in the figure shown below. It is imperative to emphasize that this correction does not alter the conclusions presented in the paper. None of the 10 month-old nTg or M20 mice injected with PBS exhibited appreciable pathology.

Fig. 7
figure 1

Exacerbation of Microgliosis in αSyn PFF-seeded dTg mice. A Representative images showing IHC using antibodies specific for Iba1 to compare nTg, M20, L85, and dTg mice injected with PBS or αSyn PFFs at 8 (2 m.p.i.) and 10 months (4 m.p.i.) of age as indicated, and corresponding heatmap depicting regional Iba1 percent positivity. The increase in microglial proliferation is illustrated by the color change from blue (minimum of Iba1 percent positivity) to orange (maximum of Iba1 percent positivity). Gray indicates regions were not quantified during this study. B Quantitation of Iba1 percent positivity comparing the retrosplenial cortex, CA1 of the hippocampus, and the entorhinal cortex within each cohort. Two-Way ANOVA followed by Holm-Sidak’s multiple comparisons test was used for statistical analysis (n = 8,8,13; 6,8,12; 8,8,10; 6,8,11). Data are presented as mean + / − SEM. Scale bar: 500 μm

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The authors sincerely regret any confusion this oversight may have caused and appreciate the understanding of the readership.

  1. Lloyd GM, Dhillon J-KS, Gorion K-MM, Riffe C, Fromholt SE, Xia Y, et al. Collusion of α-Synuclein and Aβ aggravating co-morbidities in a novel prion-type mouse model. Mol Neurodegener. 2021;16:63. https://doi.org/10.1186/s13024-021-00486-9.

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Authors and Affiliations

  1. Department of Neuroscience, College of Medicine, University of Florida, Gainesville, FL, 32610, USA

    Grace M. Lloyd, Jess-Karan S. Dhillon, Kimberly-Marie M. Gorion, Cara Riffe, Susan E. Fromholt, Yuxing Xia, Benoit I. Giasson & David R. Borchelt

  2. Center for Translational Research in Neurodegenerative Disease, College of Medicine, University of Florida, Gainesville, FL, 32610, USA

    Grace M. Lloyd, Jess-Karan S. Dhillon, Kimberly-Marie M. Gorion, Cara Riffe, Susan E. Fromholt, Yuxing Xia, Benoit I. Giasson & David R. Borchelt

  3. McKnight Brain Institute, College of Medicine, University of Florida, Gainesville, FL, 32610, USA

    Benoit I. Giasson & David R. Borchelt

Authors
  1. Grace M. LloydView author publications

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  6. Yuxing XiaView author publications

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Corresponding authors

Correspondence to Benoit I. Giasson or David R. Borchelt.

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Lloyd, G.M., Dhillon, JK.S., Gorion, KM.M. et al. Correction: Collusion of α-Synuclein and Aβ aggravating co-morbidities in a novel prion-type mouse model. Mol Neurodegeneration 19, 17 (2024). https://doi.org/10.1186/s13024-024-00710-2

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中文翻译：
更正：α-突触核蛋白和 Aβ 的共谋加剧了新型朊病毒型小鼠模型的并发症

更正：分子神经变性 16, 63 (2021)

https://doi.org/10.1186/s13024-021-00486-9

作者希望纠正原始文章 [1] 图 7A 中的错误。我们已经确定，A 组中显示的 10 个月大、注射 PBS 的非转基因 (nTg) 小鼠半脑的代表性图像是不正确的。由于数字文件名的标签错误，显示的大脑图像实际上来自 10 个月大、注射 PBS 的野生型 αSyn (M20) 动物。下图提供了图 7A 的校正面板。必须强调的是，这一更正不会改变论文中提出的结论。注射 PBS 的 10 个月大 nTg 或 M20 小鼠均未表现出明显的病理学。

图7
图1

αSyn PFF 接种的 dTg 小鼠中小胶质细胞增生的恶化。A代表性图像显示使用 Iba1 特异性抗体对 8 (2 mpi) 和 10 个月 (4 mpi) 龄注射 PBS 或 αSyn PFF 的 nTg、M20、L85 和 dTg 小鼠进行 IHC 比较（如图所示），以及描绘区域的相应热图Iba1% 阳性。小胶质细胞增殖的增加通过颜色从蓝色（Iba1 阳性百分比的最小值）到橙色（Iba1 阳性百分比的最大值）的变化来说明。灰色表示本研究期间未对区域进行量化。B比较每个队列内的压后皮质、海马 CA1 和内嗅皮质的 Iba1 阳性百分比定量。采用双向方差分析和 Holm-Sidak 多重比较检验进行统计分析（n  = 8,8,13；6,8,12；8,8,10；6,8,11）。数据以平均值+/- SEM 表示。比例尺：500 μm

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作者对这一疏忽可能造成的任何混乱表示诚挚的歉意，并感谢读者的理解。

  1. Lloyd GM、Dhillon J-KS、Gorion K-MM、Riffe C、Fromholt SE、Xia Y 等。 α-突触核蛋白和 Aβ 的共谋加剧了新型朊病毒型小鼠模型的合并症。摩尔神经退行性疾病。 2021；16:63。 https://doi.org/10.1186/s13024-021-00486-9。

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作者和单位

  1. 佛罗里达大学医学院神经科学系，盖恩斯维尔，佛罗里达州，32610，美国

    Grace M. Lloyd、Jess-Karan S. Dhillon、Kimberly-Marie M. Gorion、Cara Riffe、Susan E. Fromholt、Yuxing Xia、Benoit I. Giasson 和 David R. Borchelt

  2. 佛罗里达大学医学院神经退行性疾病转化研究中心，盖恩斯维尔，佛罗里达州，32610，美国

    Grace M. Lloyd、Jess-Karan S. Dhillon、Kimberly-Marie M. Gorion、Cara Riffe、Susan E. Fromholt、Yuxing Xia、Benoit I. Giasson 和 David R. Borchelt

  3. 佛罗里达大学医学院麦克奈特脑研究所，盖恩斯维尔，佛罗里达州，32610，美国

    伯努瓦·贾森 (Benoit I. Giasson) 和大卫·R·博切尔特 (David R. Borchelt)

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  1. Grace M. Lloyd查看作者出版物

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Lloyd, GM、Dhillon, JK.S.、Gorion, KM.M.等人。更正：α-突触核蛋白和 Aβ 的共谋加剧了新型朊病毒型小鼠模型中的并发症。摩尔神经变性 19 , 17 (2024)。 https://doi.org/10.1186/s13024-024-00710-2

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