Abstract

The study investigates the association of coffee consumption and odds of osteoporosis/osteopenia among individuals older than 50 years in the United States. In NHANES 2005–2014, drinking ≤ 2 cups(16 oz) of coffee per day can reduce the risk of osteoporosis/osteopenia at the femoral neck and lumbar spine in US adults. Previous epidemiological studies revealed that daily coffee intake reduced the incidence of a cluster of metabolic diseases, however, the link between coffee consumption and prevalence of osteoporosis/osteopenia still remain inconclusive and awaits further confirmation. Based on data collection from 2005 to 2014 survey cycles, National Health and Nutrition Examination Survey (NHANES), a sample size of 8789 participants aged 50 and above completing two nonconsecutive 24-h dietary recalls were eventually enrolled for analysis. Associations between coffee intake and BMD were assessed. A lower odds of having femoral neck osteopenia/osteoporosis (FOO) was observed in participants with moderate intake of coffee (≤ 2 cups per day), rather than other beverages (OR 0.83; 95% CI, 0.72–0.95; p = 0.01). Moreover, significant associations existed between daily caffeine intake and both FOO and lumbar-spine osteopenia/osteoporosis (LOO). Even after adjusting for decaffeinated coffee, tea, sugar-sweetened beverages (SSBs), and coffee consumption, osteopenia and osteoporosis the odds remained lower at both femoral and neck levels. Our data suggest moderate habitual coffee intake (≤ 2 cups coffee/day) would have protective effects against osteoporosis/osteopenia of femoral neck and spine, among US adults over the age of 50.

中文翻译：

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咖啡饮用量与中年和老年美国人骨质减少和骨质疏松症的发生率：NHANES 2005-2014 年横断面研究

摘要

该研究调查了美国 50 岁以上人群中咖啡摄入量与骨质疏松症/骨质减少症发病率之间的关系。在 NHANES 2005-2014 中，每天饮用 ≤ 2 杯（16 盎司）咖啡可以降低美国成年人股骨颈和腰椎骨质疏松症/骨质减少的风险。此前的流行病学研究表明，每天摄入咖啡可降低一系列代谢性疾病的发病率，然而，咖啡摄入量与骨质疏松症/骨质减少症患病率之间的联系仍不确定，有待进一步证实。根据国家健康与营养检查调查 (NHANES) 2005 年至 2014 年调查周期收集的数据，样本量为 8789 名 50 岁及以上的参与者，完成了两次非连续的 24 小时饮食回忆，最终纳入分析。评估了咖啡摄入量和 BMD 之间的关联。适度摄入咖啡（每天≤ 2 杯）而不是其他饮料的参与者患股骨颈骨质减少/骨质疏松症 (FOO) 的几率较低（OR 0.83；95% CI，0.72–0.95；p  = 0.01） 。此外，每日咖啡因摄入量与 FOO 和腰椎骨质减少/骨质疏松症 (LOO) 之间存在显着关联。即使在调整了脱咖啡因咖啡、茶、含糖饮料 (SSB) 和咖啡消费、骨质减少和骨质疏松症之后，股骨和颈部水平的发生率仍然较低。我们的数据表明，对于 50 岁以上的美国成年人来说，适度习惯性咖啡摄入（≤ 2 杯咖啡/天）对预防股骨颈和脊柱骨质疏松症/骨质减少有保护作用。