Intracranial aneurysm (IA) is a common cerebrovascular disease and the leading cause of spontaneous subarachnoid hemorrhage. Recent evidence suggests that gut microbiota is involved in the pathophysiological process of IA through the gut-brain axis. However, the role of gut inflammation in the development of IA has yet to be clarified. Our study aimed to investigate whether fecal calprotectin (FC) level, a sensitive marker of gut inflammation, is correlated with the development of IA and the prognosis of patients with ruptured IA (RIA). 182 patients were collected from January 2022 to January 2023, including 151 patients with IA and 31 healthy individuals. 151 IA patients included 109 patients with unruptured IA (UIA) and 42 patients with RIA. The FC level was measured by enzyme-linked immunosorbent assay. Other detailed information was obtained from an electronic medical record system. Compared with healthy controls, the FC levels in patients with IA were increased (P < 0.0001). Patients with RIA had significantly higher FC levels than UIA patients (P < 0.0001). Moreover, the FC level in RIA patients with unfavorable outcomes was higher than in RIA patients with favorable outcomes. Logistic regression analysis showed that the elevated FC level was an independent risk factor for a 3-month poor prognosis in patients with RIA (OR=1.005, 95% CI = 1.000 -1.009, P = 0.044). Fecal calprotectin level is significantly elevated in IA patients, especially those with RIA. FC is a novel biomarker of 3-month poor outcomes in RIA patients.

中文翻译：

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粪便钙卫蛋白是预测颅内动脉瘤破裂患者临床结果的新型生物标志物

颅内动脉瘤（IA）是一种常见的脑血管疾病，也是自发性蛛网膜下腔出血的主要原因。最近的证据表明，肠道微生物群通过肠-脑轴参与 IA 的病理生理过程。然而，肠道炎症在 IA 发展中的作用尚未明确。我们的研究旨在探讨肠道炎症的敏感标志物粪便钙卫蛋白 (FC) 水平是否与 IA 的发展以及 IA 破裂 (RIA) 患者的预后相关。收集2022年1月至2023年1月期间的182例患者，其中151例IA患者和31例健康个体。151 名 IA 患者包括 109 名未破裂 IA (UIA) 患者和 42 名 RIA 患者。FC水平通过酶联免疫吸附测定法测定。其他详细信息是从电子病历系统获得的。与健康对照者相比，IA患者的FC水平升高（P < 0.0001）。RIA 患者的 FC 水平显着高于 UIA 患者 (P < 0.0001)。此外，预后不良的 RIA 患者的 FC 水平高于预后良好的 RIA 患者。Logistic回归分析显示，FC水平升高是RIA患者3个月预后不良的独立危险因素（OR=1.005，95% CI=1.000 -1.009，P=0.044）。IA 患者，尤其是 RIA 患者，粪便钙卫蛋白水平显着升高。FC 是 RIA 患者 3 个月不良预后的新型生物标志物。