Antimicrobial peptides (AMPs), found in both animals and plants, are used to fend off a wide variety of invading pathogens, such as bacteria, fungi, protozoa, viruses, etc. Their widespread distribution and defensive activity towards all different microbes lead to the successful evolution of complex multicellular organisms. In particular, AMPs target bacterial membranes and disrupt the membrane via the formation of transmembrane pores without interacting with any specific receptors. It is known that different antimicrobial peptides use different mechanisms to disrupt the membrane by forming transmembrane pores. The interaction of the antimicrobial peptide with the membrane depends on peptide charge, hydrophobicity, membrane composition, etc. Therefore, to get insights into the mechanisms of membrane disruption, it is useful to study the model membrane, as biological membranes are complex and regulated by various other proteins, cholesterol, etc. In the present review, we will primarily describe the interaction of antimicrobial peptides with phospholipid membranes, which mimic the bacterial membrane, in view of understanding the mechanism of action, various factors affecting their activity, application prospects in drug therapeutics, etc.

抗菌肽（AMP）存在于动物和植物中，用于抵御多种入侵病原体，如细菌、真菌、原生动物、病毒等。它们的广​​泛分布和对所有不同微生物的防御活性导致复杂多细胞生物的成功进化。特别是，AMP 以细菌膜为目标，通过形成跨膜孔破坏细菌膜，而不与任何特定受体相互作用。众所周知，不同的抗菌肽使用不同的机制通过形成跨膜孔来破坏膜。抗菌肽与膜的相互作用取决于肽电荷、疏水性、膜组成等。因此，为了深入了解膜破坏的机制，研究模型膜是有用的，因为生物膜很复杂，并且受到多种因素的调节。在本综述中，我们将主要描述抗菌肽与模仿细菌膜的磷脂膜的相互作用，以了解其作用机制、影响其活性的各种因素以及在抗菌肽中的应用前景。药物治疗等