: Psychiatric disorders are complex, multifactorial illnesses. It is challenging for us to understand the underlying mechanism of psychiatric disorders. In recent years, the morbidity of psychiatric disorders has increased yearly, causing huge economic losses to the society. Although some progress, such as psychotherapy drugs and electroconvulsive therapy, has been made in the treatment of psychiatric disorders, including depression, anxiety, bipolar disorder, obsessive-compulsive and autism spectrum disorders, antidepressants and psychotropic drugs have the characteristics of negative effects and high rate of relapse. Therefore, researchers continue to seek suitable interventions. cAMP response element binding protein (CREB) belongs to a protein family and is widely distributed in the majority of brain cells that function as a transcription factor. It has been demonstrated that CREB plays an important role in neurogenesis, synaptic plasticity, and neuronal growth. This review provides a 10-year update of the 2013 systematic review on the multidimensional roles of CREB-mediated transcriptional signaling in psychiatric disorders. We also summarize the classification of psychiatric disorders and elucidate the involvement of CREB and related downstream signalling pathways in psychiatric disorders. Importantly, we analyse the CREB-related signal pathways involving antidepressants and anti-psychotics to relieve the pathological process of psychiatric disorders. This review emphasizes that CREB signalling may have a vast potential to treat psychiatric disorders like depression. Furthermore, it would be helpful for the development of potential medicine to make up for the imperfection of current antidepressants and antipsychotics.

中文翻译：

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CREB：治疗精神疾病的一个有前景的治疗靶点

：精神疾病是复杂的、多因素的疾病。了解精神疾病的潜在机制对我们来说是一项挑战。近年来，精神疾病发病率逐年上升，给社会造成巨大的经济损失。尽管心理治疗药物和电休克治疗等精神疾病治疗，包括抑郁症、焦虑症、双相情感障碍、强迫症和自闭症谱系障碍，已经取得了一些进展，但抗抑郁药物和精神药物具有副作用大、疗效高的特点。复发率。因此，研究人员不断寻求合适的干预措施。cAMP反应元件结合蛋白（CREB）属于蛋白质家族，广泛分布于大多数脑细胞中，起转录因子的作用。已证明 CREB ​​在神经发生、突触可塑性和神经元生长中发挥重要作用。本综述提供了 2013 年关于 CREB ​​介导的转录信号在精神疾病中多维作用的系统综述的 10 年更新。我们还总结了精神疾病的分类，并阐明了 CREB ​​及相关下游信号通路在精神疾病中的参与。重要的是，我们分析了涉及抗抑郁药和抗精神病药的 CREB ​​相关信号通路，以缓解精神疾病的病理过程。这篇综述强调 CREB ​​信号传导可能具有治疗抑郁症等精神疾病的巨大潜力。此外，这将有助于潜在医学的发展，以弥补现有抗抑郁药和抗精神病药的缺陷。