Quinoline and its derivatives have been utilized and marketed as antibacterial, antimalarial, anticancer, hypertension, asthma (COPD), etc. The diverse pharmacological properties of quinolone are related to its chemical structure. Nowadays, it is common practice to combine at least two pharmacophores to create a single molecule with powerful pharmacological effects. This helps to synergize pharmacological qualities, enables interaction with several targets, or lessens the negative effects related to them. Various synthetic approaches which have been used in recent times for the synthesis of quinoline and its derivatives are listed in the manuscript with their merits and demerit. The structure-activity relationship relating various pharmacological actions with molecular structure and interaction with several targets has also been highlighted to provide a good comprehension to the researchers for future studies on quinoline.

中文翻译：

---

喹啉及其类似物：深入了解合成、生物活性、构效关系以及与靶标的相互作用

喹啉及其衍生物已被用作抗菌、抗疟、抗癌、高血压、哮喘（COPD）等。喹诺酮的多种药理特性与其化学结构有关。如今，通常的做法是结合至少两个药效团来创建具有强大药理作用的单个分子。这有助于协同药理特性，实现与多个靶点的相互作用，或减轻与其相关的负面影响。手稿中列出了近年来用于合成喹啉及其衍生物的各种合成方法及其优点和缺点。还强调了各种药理作用与分子结构以及与多个靶标的相互作用之间的构效关系，以便为研究人员对喹啉的未来研究提供良好的理解。