The triglyceride-glucose (TyG) index is considered a dependable biomarker for gauging insulin resistance. The atherogenic index of plasma (AIP) represents a marker reflecting atherosclerosis. However, there is currently no study specifically exploring the associations of these two biomarkers with the severity of new-onset coronary artery disease (CAD) under different glucose metabolic states. Therefore, this study aims to evaluate the correlations of these two biomarkers with CAD severity in patients newly diagnosed with CAD under various glucose metabolism conditions. Totally 570 subjects first administered coronary angiography were enrolled, including 431 first diagnosed CAD patients and 139 non-CAD patients. CAD severity was gauged by the quantity of narrowed arteries (single-vessel and multi-vessel CAD). According to WHO diabetes guidelines, glucose metabolic states were divided into normal glucose regulation (NGR), pre-diabetes mellitus (Pre-DM), and diabetes mellitus (DM). The relationships of the TyG index and AIP with CAD severity were validated by logistic regression analysis, including adjustment for traditional cardiovascular risk elements and medical treatments. Their predictive efficacy for CAD was evaluated by receiver operating characteristic (ROC) curves. The TyG index and AIP were independently correlated with CAD in accordance with logistic regression analysis (both P < 0.05). Regardless of the glucose metabolic states, there was no statistical correlation between the TyG index and CAD severity. However, AIP in NGR patients was significantly related to CAD severity (P < 0.05). The areas under the curve of the TyG index and AIP for predicting CAD were 0.682 and 0.642 (both P < 0.001), respectively, and their optimal cut-off values were 3.210 (Youden index: 0.305) and 0.095 (Youden index:0.246), respectively. The TyG index and AIP have significant associations with CAD. The TyG index had no association with CAD severity, regardless of glucose metabolic states. AIP exhibited a discernible link with CAD severity in NGR patients, but not in the pre-DM or DM populations. The TyG index and AIP have similar predictive values for new-onset CAD.

中文翻译：

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不同糖代谢状态下血浆甘油三酯-葡萄糖指数和致动脉粥样硬化指数与新发冠心病严重程度的关系

甘油三酯-葡萄糖 (TyG) 指数被认为是衡量胰岛素抵抗的可靠生物标志物。血浆致动脉粥样硬化指数（AIP）是反映动脉粥样硬化的标志物。然而，目前尚无研究专门探讨这两种生物标志物与不同糖代谢状态下新发冠状动脉疾病（CAD）严重程度的关系。因此，本研究旨在评估这两种生物标志物与不同糖代谢条件下新诊断的 CAD 患者 CAD 严重程度的相关性。共有 570 名首次接受冠状动脉造影的受试者入组，其中 431 名首次诊断的 CAD 患者和 139 名非 CAD 患者。CAD 严重程度通过狭窄动脉的数量（单血管和多血管 CAD）来衡量。根据世界卫生组织糖尿病指南，糖代谢状态分为正常糖调节（NGR）、糖尿病前期（Pre-DM）和糖尿病（DM）。TyG 指数和 AIP 与 CAD 严重程度的关系通过逻辑回归分析进行了验证，包括对传统心血管危险因素和药物治疗的调整。他们对 CAD 的预测功效通过受试者工作特征 (ROC) 曲线进行评估。根据逻辑回归分析，TyG 指数和 AIP 与 CAD 独立相关（P < 0.05）。无论葡萄糖代谢状态如何，TyG 指数与 CAD 严重程度之间不存在统计相关性。然而，NGR 患者的 AIP 与 CAD 严重程度显着相关（P < 0.05）。TyG指数和AIP预测CAD的曲线下面积分别为0.682和0.642（均P < 0.001），其最佳截断值为3.210（约登指数：0.305）和0.095（约登指数：0.246） ， 分别。TyG 指数和 AIP 与 CAD 具有显着关联。无论葡萄糖代谢状态如何，TyG 指数与 CAD 严重程度均无关。在 NGR 患者中，AIP 与 CAD 严重程度存在明显的联系，但在糖尿病前期或糖尿病人群中则不然。TyG 指数和 AIP 对新发 CAD 具有相似的预测值。