An extensive review is presented on mitochondrial structure and function, mitochondrial proteins, the outer and inner membranes, cristae, the role of F1FO-ATP synthase, the mitochondrial contact site and cristae organizing system (MICOS), the sorting and assembly machinery morphology and function, and phospholipids, in particular cardiolipin. Aspects of mitochondrial regulation under physiological and pathological conditions are outlined, in particular the role of dysregulated MICOS protein subunit Mic60 in Parkinson’s disease, the relations between mitochondrial quality control and proteins, and mitochondria as signaling organelles. A mathematical modeling approach of cristae and MICOS using mechanical beam theory is introduced and outlined. The proposed modeling is based on the premise that an optimization framework can be used for a better understanding of critical mitochondrial function and also to better map certain experiments and clinical interventions.

中文翻译：

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线粒体和 MICOS – 功能和建模

对线粒体结构和功能、线粒体蛋白、外膜和内膜、嵴、F 的作用进行了广泛的综述1F氧-ATP合酶、线粒体接触位点和嵴组织系统（MICOS）、分选和组装机器的形态和功能以及磷脂，特别是心磷脂。概述了生理和病理条件下线粒体调节的各个方面，特别是失调的 MICOS 蛋白亚基 Mic60 在帕金森病中的作用、线粒体质量控制与蛋白质之间的关系以及线粒体作为信号细胞器。介绍并概述了一种使用机械梁理论的嵴和 MICOS 数学建模方法。所提出的模型基于这样的前提：优化框架可用于更好地理解关键线粒体功能，并更好地绘制某些实验和临床干预措施。