Developed innovative compounds by integrating 1,2,4-triazole with a focus on α-glucosidase inhibition. The structures of these compounds were confirmed using various spectroscopic methods, including FT-IR, ¹H-NMR, ¹³C-NMR, and HR-MS. X-ray diffraction was used to validate structures for three specific compounds (3, 5 d, and 5 e). In vitro testing showcased the α-glucosidase inhibitory potential, notably compound 5 g with a 3-hydroxy substitution. Molecular docking studies were used to analyze compound interactions at the active site of the enzyme.

中文翻译：

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以 2-(萘-1-基)乙酸为原料的含有 4-乙基-4H-1,2,4-三唑的新型乙酰胺衍生物的结构研究并评估 α-葡萄糖苷酶抑制作用

通过整合 1,2,4-三唑开发创新化合物，重点关注 α-葡萄糖苷酶抑制。这些化合物的结构通过各种光谱方法得到证实，包括FT-IR、¹ H-NMR、¹³ C-NMR和HR-MS。X 射线衍射用于验证三种特定化合物（3、5d和5e）的结构。体外测试显示了 α-葡萄糖苷酶的抑制潜力，特别 是具有 3-羟基取代的5 g化合物。分子对接研究用于分析酶活性位点的化合物相互作用。