High levels of reactive oxygen species (ROS) are closely associated with osteoclast formation and function, resulting in bone loss. Herein, a novel ROS scavenger, named IR-ALN, based on the heptamethine cyanine (Cy7) dyes is reported. IR-ALN not only retains the inherent near-infrared (NIR) fluorescence imaging and ROS scavenging activity of Cy7 dyes, but is also selectively absorbed by the osteoclast precursor cells, inhibiting osteoclast differentiation and bone resorption activity. Moreover, IR-ALN exhibits bone-targeted accumulation in a dose-dependent manner and effectively alleviates bone and trabecular volume loss caused by X-ray. The results suggest that IR-ALN is a potential radioprotective agent that prevents radiation-induced bone loss. Furthermore, the design strategy for IR-ALN can be used as a reference for the development of new radioprotective agents.

中文翻译：

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磷酸化七次甲基染料可减轻辐射引起的骨质流失

高水平的活性氧（ROS）与破骨细胞的形成和功能密切相关，从而导致骨质流失。本文报道了一种基于七次甲基花青 (Cy7) 染料的新型 ROS 清除剂，名为 IR-ALN。IR-ALN不仅保留了Cy7染料固有的近红外（NIR）荧光成像和ROS清除活性，而且还被破骨细胞前体细胞选择性吸收，抑制破骨细胞分化和骨吸收活性。此外，IR-ALN以剂量依赖性方式表现出骨靶向积累，并有效减轻X射线引起的骨和小梁体积损失。结果表明 IR-ALN 是一种潜在的辐射防护剂，可以防止辐射引起的骨质流失。此外，IR-ALN的设计策略可以为新型辐射防护剂的开发提供参考。