Many attempts have been proposed to evaluate the linkage between the oral–gut–liver axis and the mechanisms related to the diseases’ establishment. One of them is the oral microbiota translocation into the bloodstream, liver, and gut, promoting a host dysbiosis and triggering the presence of some metabolites such as trimethylamine N-oxide (TMAO), known as a risk marker for cardiovascular disease, and especially the myocardial infarction (MI). In the present pilot study, the involvement of oral dysbiosis related to the presence of TMAO has been considered an independent component of the standard risk factors (SRs) in the development of MI, which has not been previously described in human cohorts. A positive and significant correlation of TMAO levels with Porphyromonas was identified; likewise, the increase of the genus Peptidiphaga in patients without SRs was observed. We determined that the presence of SRs does not influence the TMAO concentration in these patients. This report is the first study where the relationship between oral dysbiosis and TMAO is specified in the Mexican population. Our findings provide information on the possible contribution of the oral pathogens associated with gut dysbiosis in the development of MI, although further analysis should be performed.

中文翻译：

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墨西哥心肌梗塞患者口腔微生物组与氧化三甲胺定量的潜在关联

人们提出了许多尝试来评估口腔-肠-肝轴与疾病发生相关机制之间的联系。其中之一是口腔微生物群易位到血液、肝脏和肠道中，促进宿主生态失调，并引发一些代谢物的存在，例如三甲胺 N-氧化物 (TMAO)，它被称为心血管疾病的风险标志物，尤其是心肌梗塞（MI）。在目前的初步研究中，与 TMAO 存在相关的口腔生态失调被认为是 MI 发展中标准危险因素 (SR) 的独立组成部分，此前在人类队列中尚未对此进行过描述。TMAO 水平与卟啉单胞菌呈显着正相关；同样，在没有 SR 的患者中，观察到肽噬菌属(Peptidiphaga)的增加。我们确定 SR 的存在不会影响这些患者的 TMAO 浓度。该报告是第一份在墨西哥人群中明确口腔生态失调与 TMAO 之间关系的研究。我们的研究结果提供了与肠道菌群失调相关的口腔病原体在心肌梗死发展中可能发挥的作用的信息，尽管还需要进行进一步的分析。