Extracellular vesicle (EV) research has expanded exponentially over the last 10–15 years, with less than 100 entries in PubMed in 2007 but almost 8000 in 2022, depending on the specifics of the search terms applied. As this meteoric rise began, the field moved at a high pace, with methodology and technology evolving swiftly. This evolution has had notable impact on the stringency of the research produced. When ISEV was established in 2011, it was evident that researchers in the field needed some guidance to improve the quality of published science, as well as advice regarding the technologies being developed to support their work.

The aim of the ISEV leadership has always been to support the positive development of EV research in general. To assist with this, ISEV has published the so-called MISEV guidelines (Lotvall et al., 2014 and Thery et al., 2018). In the first version, MISEV2014, the word “requirement” was used in the title of the document, which resulted in some criticism, and therefore in 2018 the term “information” was used to better represent the overall goal of MISEV. MISEV guidelines aim to represent the consensus of the field regarding the current state of the art, and they are NOT a set of requirements for EV researchers. MISEV2014 was a short and succinct advisory text on how EV research can provide relatively conclusive results, as well as identifying some caveats that can be avoided in this field of research. Four years later, in 2018, a vast technology development had occurred, with new methods and analytical tools having been introduced to the field. The MISEV guidelines grew significantly, and many authors were recruited to contribute to the document. This effort evolved to the massive MISEV 2018 publication, which is extensively referenced, sometimes as a handbook of EV research. Indeed, if the advice in this document is applied by researchers, the likelihood that the results observed in any study depend on the EVs, are relatively likely.

Since MISEV2018, there have been even further developments in the field, including new methods of EV isolation and technologies to characterize EVs at the single-EV level. ISEV initiated a process to develop a new and updated MISEV several years ago, and an enormous effort has been employed to develop texts and advice for the version being published in the current issue of Journal of Extracellular Vesicles. The document has 1051 authors, and the whole process of compiling the document has been immense and very challenging but ultimately rewarding.

The editorial approach taken towards the MISEV document, much like the process of compiling the manuscript itself, has been extensive. In the spring of 2023, a full draft of the MISEV 2023 guidelines had been compiled, and discussions between the ISEV board and the Editorial leadership of JEV on how, and when, to submit the document for consideration by the journal ensued. The journal clarified that, although a formal review process is not required for publication of society policy documents, a process to quality assure the manuscript prior to acceptance would be employed. This included several steps.

First, the full-time scientific editor of ISEV and JEV, Sarah Williams, helped the society to harmonize the texts and the different sections of the manuscript. This required some extensive re-writing of sections, without losing the message of the text. Further, I, the Editor-in-Chief of JEV, contributed at this stage to progress some sections of the text, including certain chapters, but also the abstract. After this, the draft text went back to the ISEV board, which further processed it, before submitting an original version to JEV on 20th June, 2023. As had been clarified during early discussions, the EiC took a leading position in managing the editorial process, which included an extensive quality control procedure that saw over 30 individuals appraise either the entire document, or specified sections within it (Table S1). Many of these individuals, as well as the editorial team, are co-authors of the document, but this did not refrain any of them from commenting on shortcomings within the submitted version, as is evident in the published feedback in the supplement table of this editorial. On 21st July 2023, the EiC requested extensive revisions to the document based on the comments received during the appraisal process. Friday 3rd November 2023, the society resubmitted a considerably amended version of the work, and a second round of appraisals were performed, this time with 10 individuals who returned their feedback within 1 week. On the 10^th of November 2023, the journal requested further minor changes to the document based on some of the quality control suggestions provided by these individuals (Table S2). Finally, on the 28^th of November 2023, a further improved manuscript was submitted to the journal and, following consultation with the Deputy Editors of the journal, I, the EiC, approved the manuscript for publication. I am immensely proud of the community, the journal editorial team and those individuals who appraised the document, that this document has finally been published in JEV. I am confident that it will support the wider community with advice and suggestions to develop this field of research further.

MISEV2023 has benefited from the input of a vast number of co-authors as well as additional appraisal from a large “quality control team” provided by the journal. The previous MISEV guidelines did not benefit from this extended editorial process, but I feel that this has led to the publication of an impressive field consensus document that will be exceptionally important to the community for many years to come. Performing the roles of both Editor and appraiser, as well as being co-author of any manuscript may be unusual, but I suggest that this process has provided the best possible approach to quality assure the MISEV 2023 guidelines, as well as recognizing the contributions of all those involved. It is my belief that the whole community should be extraordinarily proud of MISEV2023.

细胞外囊泡 (EV) 研究在过去 10-15 年中呈指数级增长，2007 年 PubMed 中的条目不到 100 条，但到 2022 年将接近 8000 条，具体取决于所应用的搜索词的具体情况。随着这种迅速崛起的开始，该领域快速发展，方法论和技术迅速发展。这种演变对研究的严格性产生了显着影响。当 ISEV 于 2011 年成立时，很明显该领域的研究人员需要一些指导来提高已发表科学的质量，以及有关正在开发的技术以支持他们的工作的建议。

ISEV 领导层的目标始终是支持电动汽车研究的积极发展。为了帮助实现这一目标，ISEV 发布了所谓的 MISEV 指南（Lotvall 等人，2014 年；Thery 等人，2018 年）。在第一个版本MISEV2014中，文件标题中使用了“需求”一词，这引起了一些批评，因此2018年使用“信息”一词来更好地代表MISEV的总体目标。MISEV 指南旨在代表该领域对当前技术水平的共识，它们并不是对电动汽车研究人员的一组要求。MISEV2014 是一篇简短的咨询文本，介绍了电动汽车研究如何提供相对结论性的结果，并确定了该研究领域可以避免的一些注意事项。四年后的 2018 年，技术发生了巨大的发展，新的方法和分析工具被引入该领域。MISEV 指南显着增长，并招募了许多作者来为该文档做出贡献。这项工作演变成了 MISEV 2018 的大型出版物，该出版物被广泛引用，有时甚至作为电动汽车研究手册。事实上，如果研究人员采用本文件中的建议，则任何研究中观察到的结果依赖于 EV 的可能性相对较大。

自 MISEV2018 以来，该领域取得了进一步的发展，包括电动汽车隔离的新方法和在单电动汽车级别表征电动汽车的技术。ISEV 几年前启动了开发新的和更新的 MISEV 的过程，并且付出了巨大的努力来为最新一期《细胞外囊泡杂志》上发表的版本开发文本和建议。该文档有 1051 位作者，整个编译文档的过程是巨大的、非常具有挑战性的，但最终还是有回报的。

MISEV 文件采用的编辑方法非常广泛，就像编辑手稿本身的过程一样。2023 年春季，MISEV 2023 指南的完整草案已经编制完毕，ISEV 董事会和 JEV 的编辑领导层就如何以及何时提交该文件供期刊审议进行了讨论。该杂志澄清说，虽然出版社会政策文件不需要正式的审查程序，但在接受之前将采用一个确保稿件质量的程序。这包括几个步骤。

首先，ISEV 和 JEV 的全职科学编辑 Sarah Williams 帮助学会协调文本和手稿的不同部分。这需要对各部分进行大量重写，同时又不丢失文本的信息。此外，我，JEV 的主编，在这个阶段为推进文本的某些部分（包括某些章节和摘要）做出了贡献。此后，草案文本返回 ISEV 董事会，后者对其进行进一步处理，然后于 2023 年 6 月 20 日向 JEV 提交原始版本。正如早期讨论中所澄清的那样，EiC 在管理编辑流程方面处于领先地位，其中包括广泛的质量控制程序，超过 30 人对整个文档或其中的指定部分进行评估（表 S1）。其中许多人以及编辑团队都是该文件的共同作者，但这并没有阻止他们中的任何人对所提交版本中的缺陷发表评论，这一点在本补充表中发布的反馈中可以明显看出。社论。2023 年 7 月 21 日，EiC 要求根据评估过程中收到的意见对该文件进行广泛修改。2023 年 11 月 3 日星期五，学会重新提交了对该作品进行了大幅修改的版本，并进行了第二轮评估，这次有 10 个人在 1 周内返回了反馈。2023 年 11 月10^日，该期刊要求根据这些人提供的一些质量控制建议对文档进行进一步的小修改（表 S2）。最终，2023 年 11 月 28 日^，进一步完善的手稿被提交给该期刊，并在与该期刊副主编协商后，我（EiC）批准了该手稿的出版。我为社区、期刊编辑团队和那些评价该文档的个人感到非常自豪，该文档最终在 JEV 上发表。我相信它将为更广泛的社区提供建议和建议，以进一步发展这一研究领域。

MISEV2023 受益于大量合著者的投入以及该期刊提供的大型“质量控制团队”的额外评估。之前的 MISEV 指南并没有从这种扩展的编辑过程中受益，但我认为这导致了一份令人印象深刻的现场共识文件的发布，该文件在未来许多年对社区来说将异常重要。扮演编辑和评估员的角色，以及作为任何手稿的共同作者可能是不寻常的，但我建议这个过程提供了最好的方法来确保 MISEV 2023 指南的质量，并认可所有相关人员。我相信整个社区都应该为 MISEV2023 感到无比自豪。