BackgroundMites are ubiquitous aeroallergens found worldwide. Elucidating individual mite allergen sensitization patterns provides critical insights for managing allergic diseases. This study aimed to investigate molecular allergen (MA) sensitization patterns across different age groups and explore cluster relationships among mite‐sensitized children.MethodsWe analyzed 76 children who exhibited sensitization to at least one of the 17 distinct mite MAs through microarray testing.ResultsDermatophagoides farinae exhibited a slightly higher prevalence of sensitization compared with Dermatophagoides pteronyssinus. Der p 1/2 and Der f 1/2 demonstrated an almost 40% sensitization rate, while Der p 10/Blo t 10, Der p 20, Der p 23, and Gly d 2/Lep d 2 displayed an approximately 20% sensitization rate. Sensitization levels and ratios increased significantly with age for Der p 23 but showed numerical rises for other MAs, except for Der p 10/Blo t 10. The presence of various types of atopic diseases had only a minimal impact on sensitization profiles. Strong correlations emerged between Der f 2 and Der p 2, Der p 10 and Blo t 10, Der p 21 and Blo t 5, as well as Gly d 2 and Lep d 2. Hierarchical cluster analysis substantiated these relationships. Der p 10 and its homolog Blo t 10‐sensitive patients (15/76) were mostly seen as mono sensitization(12/15). Ten patients exhibited monosensitization to Der p 20, suggesting a possible association with scabies infection.ConclusionIn children, mite sensitization diversity and levels increased with age. The presence of significant correlations/cluster relationships among these sensitizations underscores homologies among specific MAs.

中文翻译：

---

土耳其儿童的螨过敏原致敏模式：年龄相关的变化和分子相关性

背景螨虫是世界范围内普遍存在的空气过敏原。阐明个体螨过敏原致敏模式为管理过敏性疾病提供了重要的见解。本研究旨在调查不同年龄组的分子过敏原 (MA) 致敏模式，并探讨螨过敏儿童之间的聚类关系。方法我们通过微阵列测试分析了 76 名对 17 种不同螨 MA 中的至少一种表现出过敏的儿童。结果粉尘螨表现出与屋尘螨相比，致敏发生率略高。Der p 1/2 和 Der f 1/2 显示出几乎 40% 的致敏率，而 Der p 10/Blo t 10、Der p 20、Der p 23 和 Gly d 2/Lep d 2 显示出大约 20% 的致敏率速度。Der p 23 的致敏水平和比率随着年龄的增长而显着增加，但除 Der p 10/Blo t 10 外，其他 MA 的致敏水平和比率均呈上升趋势。各种类型特应性疾病的存在对致敏情况的影响极小。Der f 2 和 Der p 2、Der p 10 和 Blo t 10、Der p 21 和 Blo t 5 以及 Gly d 2 和 Lep d 2 之间出现了很强的相关性。层次聚类分析证实了这些关系。Der p 10 及其同系物 Blo t 10 敏感患者 (15/76) 大多被视为单一致敏 (12/15)。10 名患者表现出对 Der p 20 的单一敏感性，这表明可能与疥疮感染有关。结论在儿童中，螨虫致敏多样性和水平随着年龄的增长而增加。这些敏化之间存在显着的相关性/聚类关系强调了特定 MA 之间的同源性。