Novel biomaterials suitable for bone tissue engineering are currently in demand, and reformulating natural and synthetic biomaterials has caught scientists' attention. Cellulose and collagen have been utilized in biomedical fields. This research aimed to fabricate collagen-cellulose-poly(l-lactide) (Col-Cel-PLL) scaffold using collagen, cellulose, and poly( l-lactide) through electrospinning and radiofrequency plasma treatment and to examine the scaffold's physicochemical and biological properties. Fourier transform infrared spectroscopy revealed its chemistry, and scanning electron microscopy showed fine interconnecting microfibrous fibers; it was super-hydrophilic with low crystallinity (25.59%) and great Young's modulus (163.940 ± 8.008 MPa), and it was reasonably degraded. Regarding biological properties, the scaffold was biocompatible by supporting cell attachment and viability. Cells on the Col-Cel-PLL produced high total protein levels and collagen deposition. However, the alkaline phosphatase activity was significantly low.

中文翻译：

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通过静电纺丝和等离子体辅助制造的胶原-纤维素-聚（L-丙交酯）支架，用于骨组织工程应用

目前需要适合骨组织工程的新型生物材料，并且重新配制天然和合成生物材料引起了科学家的关注。纤维素和胶原蛋白已应用于生物医学领域。本研究旨在利用胶原蛋白、纤维素和聚( L-丙交酯)通过静电纺丝和射频等离子体处理制备胶原-纤维素-聚( L-丙交酯)(Col-Cel-PLL)支架 ，并检测支架的理化和生物学特性。 。傅里叶变换红外光谱揭示了其化学性质，扫描电子显微镜显示了精细的互连微纤维；它具有超亲水性，结晶度低（25.59%），杨氏模量大（163.940±8.008 MPa），且降解合理。关于生物学特性，支架通过支持细胞附着和活力而具有生物相容性。Col-Cel-PLL 上的细胞产生高水平的总蛋白水平和胶原蛋白沉积。然而，碱性磷酸酶活性明显较低。