Pancreatic cancer liver metastases show high levels of immunosuppressive macrophages, which promote tumor growth. We found that blocking the efferocytosis pathway during early-stage metastasis in a mouse model inhibited the development of immunosuppressive activity in monocyte-derived macrophages, which restored T cell activation and reduced the metastatic tumor burden.

中文翻译：

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通过胞吞作用清除死亡细胞促进胰腺癌肝转移

胰腺癌肝转移显示出高水平的免疫抑制巨噬细胞，可促进肿瘤生长。我们发现，在小鼠模型的早期转移过程中阻断胞吞途径可以抑制单核细胞来源的巨噬细胞免疫抑制活性的发展，从而恢复 T 细胞活化并减少转移性肿瘤负担。