A method for carbon isotope exchange involving a metal-catalysed metathesis reaction of in situ formed acyl chlorides is demonstrated. The platform provides access to 13C- or 14C-enriched carboxylic acids, including natural products and pharmaceuticals, without the need for radioactive gases, using a single carboxylic acid carbon donor.

中文翻译：

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通过金属催化官能团复分解进行药物放射性标记的碳同位素交换

证明了一种碳同位素交换方法，涉及原位形成的酰氯的金属催化复分解反应。该平台使用单一羧酸碳供体，无需放射性气体即可获取富含 13C 或 14C 的羧酸，包括天然产物和药物。