Cancer is defined as the unchecked expansion of aberrant cells. Radiation, chemotherapy, and surgery are currently used in combination to treat cancer. Traditional drug delivery techniques kill healthy proliferating cells when used over prolonged periods of time in cancer chemotherapy. Due to the fact that the majority of tumor cells do not infiltrate right away, this is particularly true when treating solid tumors. A targeted drug delivery system (TDDS) is a tool that distributes medication to a selected bioactive location in a controlled manner. Nanotechnology-based delivery techniques are having a substantial impact on cancer treatment, and polymers are essential for making nanoparticulate carriers for cancer therapy. The advantages of nanotherapeutic drug delivery systems (NDDS) in terms of technology include longer half-life, improved biodistribution, longer drug circulation time, regulated and sustained drug release, flexibility in drug administration method, higher drug intercellular concentration, and others. The benefits and drawbacks of cancer nanomedicines, such as polymer-drug conjugates, micelles, dendrimers, immunoconjugates, liposomes, and nanoparticles, are discussed in this work, along with the most recent findings on polymer-based anticancer drugs.

中文翻译：

---

生物活性纳米材料在癌症治疗中的先进靶向药物输送

癌症被定义为异常细胞不受控制的扩张。目前，放射、化疗和手术联合使用来治疗癌症。传统的药物输送技术在癌症化疗中长时间使用时会杀死健康的增殖细胞。由于大多数肿瘤细胞不会立即浸润，因此在治疗实体瘤时尤其如此。靶向药物输送系统 (TDDS) 是一种以受控方式将药物分配到选定的生物活性位置的工具。基于纳米技术的递送技术对癌症治疗产生重大影响，而聚合物对于制造用于癌症治疗的纳米颗粒载体至关重要。纳米治疗药物递送系统（NDDS）在技术方面的优势包括更长的半衰期、改善的生物分布、更长的药物循环时间、调节和持续的药物释放、给药方法的灵活性、更高的药物细胞间浓度等。这项工作讨论了癌症纳米药物（例如聚合物药物缀合物、胶束、树枝状聚合物、免疫缀合物、脂质体和纳米颗粒）的优点和缺点，以及基于聚合物的抗癌药物的最新发现。