The purpose of this study was to describe the clinical features, management, outcomes, and diagnostic pitfalls in a large series of patients with ocular neuromyotonia. Retrospective cohort. Patients diagnosed with ocular neuromyotonia from January 1, 2004, through January 1, 2023, seen at one of the 3 Mayo Clinic sites in Rochester, MN, Scottsdale, AZ, and Jacksonville, FL, comprised the study population. We ascertained patients with ocular neuromyotonia through a search using the medical records database. Only patients with an observed episode of ocular neuromyotonia were included and the medical records were reviewed. The main outcome measures were clinical features and outcomes of patients with ocular neuromyotonia. Forty-two patients who were diagnosed with ocular neuromyotonia were included. The median age was 58 years (range, 16-80 years). A history of cranial radiation therapy was present in 39 patients (93%). The sixth cranial nerve was involved in 31 patients (74%). Bilateral disease was found in 2 patients (5%). The median time from onset of diplopia to diagnosis was 8 months (range, 1 month-25 years), with a high rate of initial misdiagnosis in 52%. Twenty of 42 patients (48%) were treated with oral medication, of whom 95% had significant improvement or resolution of symptoms. Prior cranial irradiation is the most common cause for ocular neuromyotonia, affecting the sixth cranial nerve most often. Although delayed and initial misdiagnosis is common, most patients show improved symptoms on medical treatment.

中文翻译：

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眼神经肌强直：临床特征、诊断和结果

本研究的目的是描述大量眼神经肌强直患者的临床特征、治疗、结果和诊断陷阱。回顾性队列。研究人群包括从 2004 年 1 月 1 日到 2023 年 1 月 1 日期间在明尼苏达州罗切斯特、亚利桑那州斯科茨代尔和佛罗里达州杰克逊维尔的 3 个梅奥诊所之一就诊的被诊断为眼神经肌强直的患者。我们通过使用医疗记录数据库进行搜索，确定了患有眼神经肌强直的患者。仅纳入观察到眼部神经肌强直发作的患者并审查病历。主要结局指标是眼神经肌强直患者的临床特征和结局。包括 42 名被诊断为眼神经肌强直的患者。中位年龄为 58 岁（范围：16-80 岁）。 39 名患者 (93%) 有颅脑放射治疗史。 31 例患者（74%）第六脑神经受累。 2 名患者（5%）发现双侧疾病。从复视发病到确诊的中位时间为8个月（范围1个月至25年），初次误诊率高达52%。 42 名患者中的 20 名（48%）接受了口服药物治疗，其中 95% 的症状得到显着改善或缓解。先前的颅脑照射是眼神经肌强直的最常见原因，最常影响第六脑神经。尽管延迟诊断和初始误诊很常见，但大多数患者在治疗后症状有所改善。