Obesity triggers inflammatory responses in the microenvironment of white adipose tissue, resulting in chronic systemic inflammation and the subsequent development of non-communicable diseases, including type 2 diabetes, coronary heart disease, and breast cancer. Current therapy approaches for obesity-induced non-communicable diseases persist in prioritizing symptom remission while frequently overlooking the criticality of targeting and alleviating inflammation at its source. Accordingly, this review highlights the importance of the microenvironment of obese white adipose tissue and the promising potential of employing immunotherapy to target it as an effective therapeutic approach for non-communicable diseases induced by obesity. Additionally, this review discusses the challenges and offers perspective about the immunotherapy targeting the microenvironment of obese white adipose tissue.

中文翻译：

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针对肥胖白色脂肪组织微环境的免疫疗法：关注非传染性疾病

肥胖会引发白色脂肪组织微环境中的炎症反应，导致慢性全身炎症以及随后发生的非传染性疾病，包括2型糖尿病、冠心病和乳腺癌。目前针对肥胖引起的非传染性疾病的治疗方法坚持优先考虑症状缓解，而经常忽视从根源上瞄准和减轻炎症的重要性。因此，这篇综述强调了肥胖白色脂肪组织微环境的重要性，以及利用免疫疗法将其作为治疗肥胖引起的非传染性疾病的有效方法的前景。此外，这篇综述讨论了挑战，并提供了针对肥胖白色脂肪组织微环境的免疫疗法的观点。