Eph receptors are the largest subfamily of receptor tyrosine kinases, and they have been shown to play a crucial role in glioma. The EphB3 receptor is a member of this family, and its effect on the invasion, migration and proliferation of glioma cells was examined in this study. It was found that the expression of EphB3 was decreased in glioma specimens with increasing tumor grade. Additionally, the U87MG and U251 cell lines showed low levels of EphB3 expression. This finding was consistent with the negative correlation between EphB3 expression in glioma tissues and tumor grade.

中文翻译：

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EphB3受体通过抑制EGFR-PI3K/AKT信号通路抑制胶质瘤的侵袭、迁移和增殖

Eph受体是受体酪氨酸激酶最大的亚家族，已被证明在神经胶质瘤中发挥着至关重要的作用。 EphB3受体是该家族的一员，本研究探讨了其对胶质瘤细胞侵袭、迁移和增殖的影响。研究发现，随着肿瘤分级的增加，胶质瘤标本中EphB3的表达量降低。此外，U87MG 和 U251 细胞系显示出低水平的 EphB3 表达。这一发现与胶质瘤组织中EphB3表达与肿瘤分级之间的负相关一致。