Advances in hiPSC isolation and reprogramming and hPSC-CM differentiation have prompted their therapeutic application and utilization for evaluating potential cardiovascular safety liabilities. In this perspective, we showcase key efforts toward the large-scale production of hiPSC-CMs, implementation of hiPSC-CMs in industry settings, and recent clinical applications of this technology. The key observations are a need for traceable gender and ethnically diverse hiPSC lines, approaches to reduce cost of scale-up, accessible clinical trial datasets, and transparent guidelines surrounding the safety and efficacy of hiPSC-based therapies.

中文翻译：

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使用人类多能干细胞衍生的心肌细胞加强心脏治疗管道

hiPSC 分离和重编程以及 hPSC-CM 分化方面的进展促进了它们的治疗应用和用于评估潜在的心血管安全隐患。从这个角度来看，我们展示了 hiPSC-CM 大规模生产、hiPSC-CM 在工业环境中的实施以及该技术最近的临床应用的关键努力。主要观察结果是需要可追踪的性别和种族多样化的 hiPSC 系、降低规模扩大成本的方法、可访问的临床试验数据集以及围绕基于 hiPSC 的疗法的安全性和有效性的透明指南。