Allogeneic transplantation of pancreatic islets for patients with difficult-to-control diabetes mellitus is severely hampered by the requirement for continuous immunosuppression and its associated morbidity. We report that allogeneic transplantation of genetically engineered (B2M, CIITA, CD47), primary, hypoimmune, pseudo-islets (p-islets) results in their engraftment into a fully immunocompetent, diabetic non-human primate wherein they provide stable endocrine function and enable insulin independence without inducing any detectable immune response in the absence of immunosuppression. Hypoimmune primary p-islets may provide a curative cell therapy for type 1 diabetes mellitus.

中文翻译：

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免疫功能低下的胰岛在完全免疫功能的非人灵长类动物中进行同种异体移植后实现了胰岛素独立

由于需要持续免疫抑制及其相关的发病率，对难以控制的糖尿病患者进行同种异体胰岛移植受到严重阻碍。我们报告说，基因工程（B2M、CIITA、CD47）、原代、低免疫、伪胰岛（p-胰岛）的同种异体移植导致它们植入完全免疫功能的糖尿病非人灵长类动物中，其中它们提供稳定的内分泌功能并能够在没有免疫抑制的情况下，胰岛素独立性不会诱导任何可检测的免疫反应。免疫低下的初级 p-胰岛可以为 1 型糖尿病提供治愈性细胞疗法。