Telocytes are unique mesenchymal cells characterized by multiple remarkably long cytoplasmic extensions that extend hundreds of micron away from the cell body. Through these extensions, telocytes establish a 3-dimensional network by connecting with other telocytes and various cell types within the tissue. In the intestine, telocytes have emerged as an essential component of the stem cell niche, providing Wnt proteins that are critical for the proliferation of stem and progenitor cells. However, the analysis of single-cell RNA sequencing has revealed other stromal populations and mechanisms for niche organization, raising questions about the role of telocytes as a component of the stem cell niche. This review explores the current state-of-the-art, existing controversies, and potential future directions related to telocytes in the luminal gastrointestinal tract.

中文翻译：

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胃肠道腔内的特洛细胞

特洛细胞是独特的间充质细胞，其特征是多个非常长的细胞质延伸，延伸到距细胞体数百微米远。通过这些延伸，远程细胞通过与组织内的其他远程细胞和各种细胞类型连接来建立 3 维网络。在肠道中，远程细胞已成为干细胞生态位的重要组成部分，提供对干细胞和祖细胞增殖至关重要的 Wnt 蛋白。然而，单细胞 RNA 测序分析揭示了其他基质群体和生态位组织机制，引发了关于特细胞作为干细胞生态位组成部分的作用的问题。这篇综述探讨了与胃肠道内的特细胞相关的当前最新技术、现有争议以及潜在的未来方向。