Prenatal iron (Fe) exposure has been associated with learning and cognitive impairments, which may be linked to oxidative stress resulting from elevated Fe levels and harm to the vulnerable brain. has contributed to our understanding of molecular mechanisms involved in neurological conditions. This study aims to explore Fe toxicity during development, assessing oxidative stress and investigating behaviors in flies that are related to neurological conditions in humans. To achieve this goal, flies were exposed to Fe during the developmental period, and biochemical and behavioral analyses were conducted. The results indicated that 20 mM Fe decreased fly hatching by 50 %. At 15 mM, Fe exposure increased lipid peroxidation, and GSH levels decreased starting from 5 mM of Fe. Superoxide Dismutase activity was enhanced at 15 mM, while Glutathione S-Transferase activity was inhibited from 5 mM. Although chronic Fe exposure did not alter acetylcholinesterase (AChE) activity, flies exhibited reduced locomotion, increased grooming, and antisocial behavior from 5 mM of Fe. This research highlights potential Fe toxicity risks during development and underscores the utility of in unraveling neurological disorders, emphasizing its relevance for future research.

中文翻译：

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发育期铁暴露诱导果蝇运动改变：探索与氧化应激的潜在关联

产前接触铁（Fe）与学习和认知障碍有关，这可能与铁水平升高引起的氧化应激以及对脆弱大脑的伤害有关。有助于我们理解神经系统疾病的分子机制。本研究旨在探索发育过程中的铁毒性，评估氧化应激并研究果蝇与人类神经系统疾病相关的行为。为了实现这一目标，果蝇在发育期间接触铁，并进行生化和行为分析。结果表明，20 mM Fe 可使苍蝇孵化率降低 50%。在 15 mM 浓度下，Fe 暴露增加了脂质过氧化，GSH 水平从 5 mM Fe 开始下降。超氧化物歧化酶活性在 15 mM 时增强，而谷胱甘肽 S-转移酶活性从 5 mM 开始受到抑制。虽然长期接触铁不会改变乙酰胆碱酯酶 (AChE) 活性，但 5 mM 铁的果蝇表现出运动减少、梳理行为增加和反社会行为。这项研究强调了发育过程中潜在的铁毒性风险，并强调了其在解决神经系统疾病方面的效用，强调了其与未来研究的相关性。