is a common member of the human skin and nose microbiomes and a frequent cause of invasive infections. Transducing phages accomplish the horizontal transfer of resistance and virulence genes by mispackaging of mobile-genetic elements, contributing to severe, therapy-refractory infections. Lytic phages on the other hand can be interesting candidates for new anti- phage therapies. Despite the importance of phages, we are only beginning to unravel phage interactions. Recent studies shed new light on phage diversity, host range, and receptor specificities. Modulation of cell wall teichoic acids, the major phage receptor structures, along with other phage defense mechanisms, are crucial determinants for susceptibility to different phage groups.

中文翻译：

---

机会性病原体表皮葡萄球菌的噬菌体敏感性决定因素

是人类皮肤和鼻子微生物组的常见成员，也是侵袭性感染的常见原因。转导噬菌体通过移动遗传元件的错误包装来实现耐药性和毒力基因的水平转移，从而导致严重的难治性感染。另一方面，裂解噬菌体可能是新的抗噬菌体疗法的有趣候选者。尽管噬菌体很重要，但我们才刚刚开始解开噬菌体相互作用。最近的研究为噬菌体多样性、宿主范围和受体特异性提供了新的线索。细胞壁磷壁酸（主要噬菌体受体结构）的调节以及其他噬菌体防御机制是对不同噬菌体群体易感性的关键决定因素。