Cardiovascular disease is frequent in type 2 diabetes mellitus (T2DM). We investigated the relationship between skin autofluorescence (SAF) of advanced glycation end-products and later cardiovascular events (CVEs) in patients with T2DM. We conducted a retrospective analysis of 504 patients hospitalized for uncontrolled and/or complicated T2DM between 2009 and 2017. SAF was measured using an AGE-Reader. Participants were followed up from admission to December 2020, for the onset of a CVE (myocardial infarction, stroke, revascularization procedures or cardiovascular death). The relationship between SAF and CVE was analyzed by multivariable Cox regression. Log-rank curves were used to compare CVE-free survival in patients whose SAF at admission was above versus below the whole-population median. The analysis was repeated in subjects without/with macroangiopathy (defined as myocardial infarction, stroke, peripheral revascularization) at baseline. During 54 months of follow-up, 69 (13.7%) patients had a CVE. Baseline SAF was significantly higher in patients with T2DM who later experienced a CVE (2.89 ± 0.70 arbitrary units versus 2.64 ± 0.62 in others, = 0.002). This relationship was significant after adjusting for age, sex, conventional risk factors (diabetes duration, HbA1c, arterial hypertension, dyslipidemia, smoking, body mass index), vascular complications, C-reactive protein, and treatments for diabetes. The CVE-free survival curves differed between subjects whose SAF was above the whole-population median (log-rank: = 0.002) and those whose SAF was above the macroangiopathy-free sub-population median (log-rank: = 0.016). SAF of advanced glycation end-products was related to a higher incidence of later CVE in patients with T2DM.

中文翻译：

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晚期糖基化终产物的皮肤自发荧光与 2 型糖尿病新心血管事件相关：一项纵向观察研究

心血管疾病在 2 型糖尿病 (T2DM) 中很常见。我们研究了 T2DM 患者晚期糖基化终产物的皮肤自发荧光 (SAF) 与后期心血管事件 (CVE) 之间的关系。我们对 2009 年至 2017 年间因未控制和/或复杂 T2DM 住院的 504 名患者进行了回顾性分析。SAF 使用 AGE-Reader 进行测量。从入院到 2020 年 12 月，对参与者进行随访，了解 CVE（心肌梗死、中风、血运重建手术或心血管死亡）的发生情况。通过多变量Cox回归分析SAF和CVE之间的关系。对数秩曲线用于比较入院时 SAF 高于和低于总体中位数的患者的无 CVE 生存率。在基线时没有/患有大血管病（定义为心肌梗死、中风、外周血运重建）的受试者中重复进行分析。在 54 个月的随访期间，69 名 (13.7%) 患者出现 CVE。后来经历 CVE 的 T2DM 患者的基线 SAF 显着较高（2.89 ± 0.70 任意单位，而其他患者为 2.64 ± 0.62，= 0.002）。在调整年龄、性别、传统危险因素（糖尿病病程、HbA1c、动脉高血压、血脂异常、吸烟、体重指数）、血管并发症、C反应蛋白和糖尿病治疗后，这种关系非常显着。 SAF 高于总体中位数（对数秩：= 0.002）的受试者和 SAF 高于无大血管病亚群中位数（对数秩：= 0.016）的受试者之间的无 CVE 生存曲线不同。晚期糖基化终末产物的 SAF 与 T2DM 患者后期 CVE 的较高发生率相关。