To investigate the quality of life (QoL) and the impact of caregiving in family caregivers of hematological cancer patients and its association with patient symptom burden. A cross-sectional study including Danish patients (n = 375) and caregivers (n = 140). Caregivers completed scales for anxiety and depression using the Hospital Anxiety and Depression Scale, sleep quality using the Pittsburgh Sleep Quality Index, health related QoL using the 12-item Short-Form Health Survey, and caregiver roles using the Caregiver Roles and Responsibilities Scale. Patients reported symptoms using the MD Anderson Symptom Inventory. Analysis of covariance was used to examine associations between patient symptom burden and caregivers' QoL outcomes. The results show that caregivers experience sleep difficulties, moderate anxiety, and reduced QoL. Patient symptom burden was significantly associated with caregiver anxiety (p = 0.009), and mental well-being (p = 0.002), while patient treatment status was a significant factor associated with caregiver anxiety (p = 0.016), depression (p = 0.009), emotional well-being (p = 0.002), and sleep (p = 0.01). Caregivers of patients with hematological cancers undergoing active treatment face a high symptom burden, which significantly impacts their QoL, including sleep, psychological well-being, and emotional health. Patients reported a high symptom burden, and patient symptom burden was significantly associated with caregiver QoL. Adequate patient and caregiver support is needed to promote their well-being and mitigate adverse health effects in caregivers, and this should be acknowledged in the context of caring for patients with hematological cancer.

中文翻译：

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血液癌症患者家庭护理人员的生活质量和症状负担：丹麦全国横断面研究

调查血液癌症患者家庭护理人员的生活质量 (QoL) 和护理的影响及其与患者症状负担的关系。一项横断面研究，包括丹麦患者 (n = 375) 和护理人员 (n = 140)。护理人员使用医院焦虑和抑郁量表填写焦虑和抑郁量表，使用匹兹堡睡眠质量指数填写睡眠质量，使用 12 项简短健康调查填写健康相关的生活质量，使用护理人员角色和责任量表填写护理人员角色。患者使用 MD 安德森症状清单报告症状。协方差分析用于检查患者症状负担与护理人员生活质量结果之间的关联。结果表明，护理人员会出现睡眠困难、中度焦虑和生活质量下降的情况。患者症状负担与护理人员焦虑 (p = 0.009) 和心理健康 (p = 0.002) 显着相关，而患者治疗状态是与护理人员焦虑 (p = 0.016)、抑郁 (p = 0.009) 相关的重要因素、情绪健康（p = 0.002）和睡眠（p = 0.01）。接受积极治疗的血液癌症患者的护理人员面临着较高的症状负担，这显着影响了他们的生活质量，包括睡眠、心理健康和情绪健康。患者报告症状负担较高，并且患者症状负担与护理人员的生活质量显着相关。需要充分的患者和护理人员支持，以促进他们的福祉并减轻护理人员对健康的不利影响，在护理血液癌症患者的背景下应该认识到这一点。